Dicer's role as an antiviral: still an enigma
Department of Medicine, Division of Infectious Diseases and Immunology
Medical Subject Headings
Animals; Antiviral Agents; Caenorhabditis elegans; DEAD-box RNA Helicases; Drosophila melanogaster; Humans; RNA, Viral; Ribonuclease III
Immunology of Infectious Disease | Immunopathology | Molecular Genetics | Virology
Dicer is a multifunctional protein that is essential across species for the generation of microRNAs, a function that is highly conserved across the plant and animal kingdoms. Intriguingly, Dicer exhibits antiviral functions in lower organisms including Drosophila melanogaster and Caenorhabditis elegans. Antiviral activity occurs via small interfering RNA production following cytoplasmic sensing of viral dsRNA. Notably, such antiviral activity has not yet been clearly demonstrated in higher organisms such as mammals. Here, we review the evidence for Dicer as an innate antiviral across species.
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Citation: Curr Opin Immunol. 2014 Feb;26:49-55. doi: 10.1016/j.coi.2013.10.015. Epub 2013 Nov 22. Link to article on publisher's site
MacKay, Christopher R.; Wang, Jennifer P.; and Kurt-Jones, Evelyn A., "Dicer's role as an antiviral: still an enigma" (2014). University of Massachusetts Medical School Faculty Publications. 800.