Antigenic peptide trimming by ER aminopeptidases--insights from structural studies
Department of Pathology
Adaptive Immunity; Aminopeptidases; Animals; Antigens; Endoplasmic Reticulum; Humans; Models, Molecular; Peptide Fragments
Immunity | Immunopathology | Molecular Biology
Generation and destruction of antigenic peptides by ER resident aminopeptidases ERAP1 and ERAP2 have been shown in the last few years to be important for the correct functioning and regulation of the adaptive immune response. These two highly homologous aminopeptidases appear to have evolved complex mechanisms well suited for their biological role in antigen presentation. Furthermore, polymorphic variability in these enzymes appears to affect their function and predispose individuals to disease. This review discusses our current understanding of the molecular mechanisms behind ERAP1/2 function as suggested by several recently determined crystallographic structures of these enzymes.
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Citation: Mol Immunol. 2013 Oct;55(3-4):212-9. doi: 10.1016/j.molimm.2013.03.002. Epub 2013 Mar 29. Link to article on publisher's site
Stratikos, Efstratios and Stern, Lawrence J., "Antigenic peptide trimming by ER aminopeptidases--insights from structural studies" (2013). University of Massachusetts Medical School Faculty Publications. 783.