University of Massachusetts Medical School Faculty Publications

Title

Antigenic peptide trimming by ER aminopeptidases--insights from structural studies

UMMS Affiliation

Department of Pathology

Date

10-1-2013

Document Type

Article

Medical Subject Headings

Adaptive Immunity; Aminopeptidases; Animals; Antigens; Endoplasmic Reticulum; Humans; Models, Molecular; Peptide Fragments

Disciplines

Immunity | Immunopathology | Molecular Biology

Abstract

Generation and destruction of antigenic peptides by ER resident aminopeptidases ERAP1 and ERAP2 have been shown in the last few years to be important for the correct functioning and regulation of the adaptive immune response. These two highly homologous aminopeptidases appear to have evolved complex mechanisms well suited for their biological role in antigen presentation. Furthermore, polymorphic variability in these enzymes appears to affect their function and predispose individuals to disease. This review discusses our current understanding of the molecular mechanisms behind ERAP1/2 function as suggested by several recently determined crystallographic structures of these enzymes.

Rights and Permissions

Citation: Mol Immunol. 2013 Oct;55(3-4):212-9. doi: 10.1016/j.molimm.2013.03.002. Epub 2013 Mar 29. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

23545452