University of Massachusetts Medical School Faculty Publications

Title

NKp30 enables NK cells to act naturally with fungi

UMMS Affiliation

Department of Medicine, Division of Infectious Disease & Immunology

Date

10-16-2013

Document Type

Article

Medical Subject Headings

Candida; Cryptococcus; HIV Infections; *Host-Pathogen Interactions; Humans; *Immune Tolerance; Killer Cells, Natural; Natural Cytotoxicity Triggering Receptor 3

Disciplines

Immunology of Infectious Disease

Abstract

NK cells have direct activity against fungal pathogens. Using an unbiased systematic approach, Li et al. (2013) find that NKp30 is a major NK cell receptor responsible for fungal recognition. Moreover, diminished NKp30 expression is associated with reduced antifungal activity in NK cells isolated from HIV-infected persons.

Rights and Permissions

Citation: Cell Host Microbe. 2013 Oct 16;14(4):369-71. doi: 10.1016/j.chom.2013.10.001. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

24139394