NKp30 enables NK cells to act naturally with fungi
Department of Medicine, Division of Infectious Disease & Immunology
Candida; Cryptococcus; HIV Infections; *Host-Pathogen Interactions; Humans; *Immune Tolerance; Killer Cells, Natural; Natural Cytotoxicity Triggering Receptor 3
Immunology of Infectious Disease
NK cells have direct activity against fungal pathogens. Using an unbiased systematic approach, Li et al. (2013) find that NKp30 is a major NK cell receptor responsible for fungal recognition. Moreover, diminished NKp30 expression is associated with reduced antifungal activity in NK cells isolated from HIV-infected persons.
Rights and Permissions
Citation: Cell Host Microbe. 2013 Oct 16;14(4):369-71. doi: 10.1016/j.chom.2013.10.001. Link to article on publisher's site
Cell host and microbe
Quintin, Jessica and Levitz, Stuart M., "NKp30 enables NK cells to act naturally with fungi" (2013). University of Massachusetts Medical School Faculty Publications. 776.