NKp30 enables NK cells to act naturally with fungi
Department of Medicine, Division of Infectious Disease & Immunology
Medical Subject Headings
Candida; Cryptococcus; HIV Infections; *Host-Pathogen Interactions; Humans; *Immune Tolerance; Killer Cells, Natural; Natural Cytotoxicity Triggering Receptor 3
Immunology of Infectious Disease
NK cells have direct activity against fungal pathogens. Using an unbiased systematic approach, Li et al. (2013) find that NKp30 is a major NK cell receptor responsible for fungal recognition. Moreover, diminished NKp30 expression is associated with reduced antifungal activity in NK cells isolated from HIV-infected persons.
Rights and Permissions
Citation: Cell Host Microbe. 2013 Oct 16;14(4):369-71. doi: 10.1016/j.chom.2013.10.001. Link to article on publisher's site
Quintin, Jessica and Levitz, Stuart M., "NKp30 enables NK cells to act naturally with fungi" (2013). University of Massachusetts Medical School Faculty Publications. 776.