University of Massachusetts Medical School Faculty Publications

UMMS Affiliation

School of Medicine; Department of Urology

Date

10-25-2013

Document Type

Article

Disciplines

Female Urogenital Diseases and Pregnancy Complications | Male Urogenital Diseases | Urology

Abstract

Overactive bladder is a highly prevalent disorder with a significant impact on quality of life. Antimuscarinic agents are commonly used, but persistence is limited due to unsatisfactory efficacy and/or tolerability. Mirabegron is the first beta-3 adrenoceptor agonist approved for the treatment of overactive bladder syndrome. This paper reviews the pharmacology, mechanism of action, efficacy, and safety of mirabegron. A PubMed search of all English articles pertaining to mirabegron was performed. An alternative to antimuscarinics, mirabegron has a unique mechanism, improves overactive bladder symptoms and quality of life, and has limited adverse effects and few contraindications.

Rights and Permissions

Citation: Res Rep Urol. 2013 Oct 25;5:147-57. doi: 10.2147/RRU.S38792. Link to article on publisher's site

Comments

This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php.

Related Resources

Link to Article in PubMed

Keywords

beta-3 agonist, incontinence, mirabegron, overactive bladder

PubMed ID

24400246

Creative Commons License

Creative Commons Attribution-Noncommercial 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License

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