School of Medicine; Department of Urology
Female Urogenital Diseases and Pregnancy Complications | Male Urogenital Diseases | Urology
Overactive bladder is a highly prevalent disorder with a significant impact on quality of life. Antimuscarinic agents are commonly used, but persistence is limited due to unsatisfactory efficacy and/or tolerability. Mirabegron is the first beta-3 adrenoceptor agonist approved for the treatment of overactive bladder syndrome. This paper reviews the pharmacology, mechanism of action, efficacy, and safety of mirabegron. A PubMed search of all English articles pertaining to mirabegron was performed. An alternative to antimuscarinics, mirabegron has a unique mechanism, improves overactive bladder symptoms and quality of life, and has limited adverse effects and few contraindications.
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Citation: Res Rep Urol. 2013 Oct 25;5:147-57. doi: 10.2147/RRU.S38792. Link to article on publisher's site
beta-3 agonist, incontinence, mirabegron, overactive bladder
Lee, Raymond; Bamberger, Mitchell H.; and Ellsworth, Pamela, "Impact of mirabegron extended-release on the treatment of overactive bladder with urge urinary incontinence, urgency, and frequency" (2013). University of Massachusetts Medical School Faculty Publications. 771.
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