Memory CD4 T cell-mediated immunity against influenza A virus: more than a little helpful
UMass Chan Affiliations
Department of PathologyDocument Type
Journal ArticlePublication Date
2013-10-01Keywords
AnimalsCD4-Positive T-Lymphocytes
Disease Models, Animal
Humans
Immunity, Cellular
*Immunologic Memory
Influenza A virus
Influenza, Human
Orthomyxoviridae Infections
T-Lymphocyte Subsets
T-Lymphocytes, Helper-Inducer
Immunity
Immunology of Infectious Disease
Immunopathology
Immunoprophylaxis and Therapy
Pathology
Metadata
Show full item recordAbstract
Recent observations have uncovered multiple pathways whereby CD4 T cells can contribute to protective immune responses against microbial threats. Incorporating the generation of memory CD4 T cells into vaccine strategies thus presents an attractive approach toward improving immunity against several important human pathogens, especially those against which antibody responses alone are inadequate to confer long-term immunity. Here, we review how memory CD4 T cells provide protection against influenza viruses. We discuss the complexities of protective memory CD4 T cell responses observed in animal models and the potential challenges of translating these observations into the clinic. Specifically, we concentrate on how better understanding of organ-specific heterogeneity of responding cells and defining multiple correlates of protection might improve vaccine-generated memory CD4 T cells to better protect against seasonal, and more importantly, pandemic influenza.Source
Arch Immunol Ther Exp (Warsz). 2013 Oct;61(5):341-53. doi: 10.1007/s00005-013-0236-z. Epub 2013 May 25. Link to article on publisher's siteDOI
10.1007/s00005-013-0236-zPermanent Link to this Item
http://hdl.handle.net/20.500.14038/30490PubMed ID
23708562Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1007/s00005-013-0236-z