Functions of FUS/TLS from DNA repair to stress response: implications for ALS
Department of Neurology; Department of Biochemistry and Molecular Pharmacology
Medical Subject Headings
Amyotrophic Lateral Sclerosis; Animals; DNA Repair; Humans; RNA Processing, Post-Transcriptional; RNA-Binding Protein FUS; Stress, Physiological
Cancer Biology | Cell Biology | Cellular and Molecular Physiology | Genetics and Genomics | Nervous System Diseases
Fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is a multifunctional DNA-/RNA-binding protein that is involved in a variety of cellular functions including transcription, protein translation, RNA splicing, and transport. FUS was initially identified as a fusion oncoprotein, and thus, the early literature focused on the role of FUS in cancer. With the recent discoveries revealing the role of FUS in neurodegenerative diseases, namely amyotrophic lateral sclerosis and frontotemporal lobar degeneration, there has been a renewed interest in elucidating the normal functions of FUS. It is not clear which, if any, endogenous functions of FUS are involved in disease pathogenesis. Here, we review what is currently known regarding the normal functions of FUS with an emphasis on DNA damage repair, RNA processing, and cellular stress response. Further, we discuss how ALS-causing mutations can potentially alter the role of FUS in these pathways, thereby contributing to disease pathogenesis.
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Citation: Sama RR, Ward CL, Bosco DA. Functions of FUS/TLS from DNA repair to stress response: implications for ALS. ASN Neuro. 2014 Jun 1;6(4). pii: 1759091414544472. doi: 10.1177/1759091414544472. Review. PubMed PMID: 25289647; PubMed Central PMCID: PMC4189536. Link to article on publisher's website
Sama, Reddy Ranjith Kumar; Ward, Catherine L.; and Bosco, Daryl A., "Functions of FUS/TLS from DNA repair to stress response: implications for ALS" (2014). University of Massachusetts Medical School Faculty Publications. 738.