MicroRNAs in alcoholic liver disease
Department of Medicine, Division of Gastroenterology
Digestive System Diseases | Gastroenterology | Hepatology | Nucleic Acids, Nucleotides, and Nucleosides | Substance Abuse and Addiction
Alcoholic liver disease (ALD) is characterized by hepatocyte damage, inflammatory cell activation and increased intestinal permeability leading to the clinical manifestations of alcoholic hepatitis. Selected members of the family of microRNAs are affected by alcohol, resulting in an abnormal miRNA profile in the liver and circulation in ALD. Increasing evidence suggests that mRNAs that regulate inflammation, lipid metabolism and promote cancer are affected by excessive alcohol administration in mouse models of ALD. This communication highlights recent findings in miRNA expression and functions as they relate to the pathogenesis of ALD. The cell-specific distribution of miRNAs, as well as the significance of circulating extracellular miRNAs, is discussed as potential biomarkers. Finally, the prospects of miRNA-based therapies are evaluated in ALD.
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Citation: Semin Liver Dis. 2015 Feb;35(1):36-42. doi: 10.1055/s-0034-1397347. Epub 2015 Jan 29. Link to article on publisher's site
Szabo, Gyongyi and Satishchandran, Abhishek, "MicroRNAs in alcoholic liver disease" (2015). University of Massachusetts Medical School Faculty Publications. 625.