University of Massachusetts Medical School Faculty Publications

Title

MicroRNAs in alcoholic liver disease

UMMS Affiliation

Department of Medicine, Division of Gastroenterology

Date

2-1-2015

Document Type

Article

Disciplines

Digestive System Diseases | Gastroenterology | Hepatology | Nucleic Acids, Nucleotides, and Nucleosides | Substance Abuse and Addiction

Abstract

Alcoholic liver disease (ALD) is characterized by hepatocyte damage, inflammatory cell activation and increased intestinal permeability leading to the clinical manifestations of alcoholic hepatitis. Selected members of the family of microRNAs are affected by alcohol, resulting in an abnormal miRNA profile in the liver and circulation in ALD. Increasing evidence suggests that mRNAs that regulate inflammation, lipid metabolism and promote cancer are affected by excessive alcohol administration in mouse models of ALD. This communication highlights recent findings in miRNA expression and functions as they relate to the pathogenesis of ALD. The cell-specific distribution of miRNAs, as well as the significance of circulating extracellular miRNAs, is discussed as potential biomarkers. Finally, the prospects of miRNA-based therapies are evaluated in ALD.

Rights and Permissions

Citation: Semin Liver Dis. 2015 Feb;35(1):36-42. doi: 10.1055/s-0034-1397347. Epub 2015 Jan 29. Link to article on publisher's site

Related Resources

Link to Article in PubMed