Shiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence
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Authors
Jandhyala, Dakshina M.Vanguri, Vijay K.
Boll, Erik J.
Lai, YuShuan (Cindy)
McCormick, Beth A.
Leong, John M.
Document Type
Journal ArticlePublication Date
2013-09-10Keywords
Communicable Diseases, EmergingDisease Outbreaks
Escherichia coli Infections
Europe
Genome, Bacterial
Humans
Shiga-Toxigenic Escherichia coli
Virulence
Bacteria
Digestive System Diseases
Immunology and Infectious Disease
Microbiology
Pathogenic Microbiology
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Show full item recordAbstract
Pathogenic Escherichia coli are genetically diverse and encompass a broad variety of pathotypes, such as enteroaggregative E. coli (EAEC) or enterohemorrhagic E. coli (EHEC), which cause distinct clinical syndromes. The historically large 2011 German outbreak of hemolytic uremic syndrome (HUS), caused by a Shiga-toxin producing E. coli (STEC) of the serotype O104:H4, illustrated the emerging importance of non-O157 STEC. STEC O104:H4, with features characteristic of both enteroaggregative E. coli and enterohemorrhagic E. coli, represents a unique and highly virulent pathotype. The German outbreak both allowed for the evaluation of several potential therapeutic approaches to STEC-induced HUS and emphasizes the importance of early and specific detection of both O157 and non-O157 STEC.Source
Infect Dis Clin North Am. 2013 Sep;27(3):631-49. doi: 10.1016/j.idc.2013.05.002. Epub 2013 Jul 24. Link to article on publisher's siteDOI
10.1016/j.idc.2013.05.002Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30313PubMed ID
24011834Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.idc.2013.05.002