University of Massachusetts Medical School Faculty Publications

Title

Malignancy and acute pulmonary embolism: risk stratification including the right to left ventricle diameter ratio in 1596 subjects

UMMS Affiliation

Department of Radiology

Publication Date

5-2013

Document Type

Article

Subjects

Pulmonary Embolism; Neoplasms

Disciplines

Cardiovascular Diseases | Neoplasms | Oncology | Radiology | Respiratory Tract Diseases

Abstract

PURPOSE: To test the hypothesis that subjects with a known malignancy at the time of acute pulmonary embolism (PE) have different clinical characteristics and predictors of 30-day all-cause mortality when compared with subjects with no known malignancy.

MATERIALS AND METHODS: A retrospective (August 2003 to March 2010) cohort of 1596 consecutive positive (for acute PE) computed tomography pulmonary angiograms (CTPAs) performed at a single, large, urban teaching hospital was separated into those from subjects with (n=835) and those from subjects without (n=761) a known malignancy. Clinical characteristics were compared between groups, and a logistic regression model determined predictors of 30-day all-cause mortality for each group.

RESULTS: Subjects with malignancy were older (60.8+/-13.9 vs. 54.5+/-18.8 y, P1.0) had a higher risk of 30-day death only among subjects with no known malignancy at the time of the CTPA (odds ratio=4.08, 95% confidence interval: 1.67-9.96).

CONCLUSIONS: Among subjects who present with acute PE, those with a malignancy had different clinical characteristics and predictors of mortality when compared with the cohort of subjects with no known malignancy. A computed tomography-derived right to left ventricular diameter ratio predicts 30-day all-cause mortality only for those subjects who do not have a malignancy.

Rights and Permissions

Citation: J Thorac Imaging. 2013 May;28(3):196-201. doi: 10.1097/RTI.0b013e3182870bf9. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Journal of thoracic imaging

PubMed ID

23478511