University of Massachusetts Medical School Faculty Publications


Obesity Notches up fatty liver

UMMS Affiliation

Program in Molecular Medicine



Document Type


Medical Subject Headings

Animals; Humans; *Lipid Metabolism; Male; Multiprotein Complexes; Proto-Oncogene Proteins c-akt; Receptors, Notch; TOR Serine-Threonine Kinases


Endocrine System Diseases | Endocrinology, Diabetes, and Metabolism | Molecular Biology


Pathologic fatty liver paradoxically accompanies obesity and type 2 diabetes despite the crippling of insulin signaling, which is normally required for fat synthesis. The developmental signaling protein Notch is a hidden regulator of lipogenesis that amplifies signal transmissions to fat production in these metabolic diseases.

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Citation: Nat Med. 2013 Aug;19(8):969-71. doi: 10.1038/nm.3293. Link to article on publisher's site

Related Resources

Link to Article in PubMed