University of Massachusetts Medical School Faculty Publications

Title

Obesity Notches up fatty liver

UMMS Affiliation

Program in Molecular Medicine

Publication Date

8-6-2013

Document Type

Article

Subjects

Animals; Humans; *Lipid Metabolism; Male; Multiprotein Complexes; Proto-Oncogene Proteins c-akt; Receptors, Notch; TOR Serine-Threonine Kinases

Disciplines

Endocrine System Diseases | Endocrinology, Diabetes, and Metabolism | Molecular Biology

Abstract

Pathologic fatty liver paradoxically accompanies obesity and type 2 diabetes despite the crippling of insulin signaling, which is normally required for fat synthesis. The developmental signaling protein Notch is a hidden regulator of lipogenesis that amplifies signal transmissions to fat production in these metabolic diseases.

Rights and Permissions

Citation: Nat Med. 2013 Aug;19(8):969-71. doi: 10.1038/nm.3293. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Nature medicine

PubMed ID

23921741