Clinical implications of current developments in genitourinary pathology
Department of Pathology
Adenocarcinoma; Carcinoma, Renal Cell; Humans; In Situ Hybridization, Fluorescence; Kidney Neoplasms; Male; Oncogene Proteins, Fusion; Pathology; Prostatic Neoplasms; Proto-Oncogene Proteins c-ets; RNA-Binding Proteins; Translational Medical Research; Tumor Markers, Biological; Urinary Bladder Neoplasms
Male Urogenital Diseases | Neoplasms | Pathology | Urogenital System
CONTEXT: Several developments in genitourinary pathology are likely to change our understanding and management of some genitourinary cancers considerably.
OBJECTIVE: To review 5 stories in genitourinary pathology: (1) fusion in the ETS (E26) gene family in prostatic adenocarcinoma; (2) insulin-like growth factor II messenger RNA-binding protein 3 (IMP3), an important prognostic biomarker for kidney and bladder cancers; (3) translocation renal cell carcinoma; (4) UroVysion fluorescence in situ hybridization test in urine cytology for detection of bladder cancer; and (5) the use of triple immunostaining for diagnosis of prostate cancer.
DATA SOURCES: Literature review and authors' personal experiences.
CONCLUSIONS: Many scientific findings have contributed recently to the understanding of the natural pathogenesis and progression of genitourinary cancers. This translational research helps in diagnosing, predicting, and potentially, treating genitourinary cancers.
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Citation: Arch Pathol Lab Med. 2013 Jul;137(7):887-93. doi: 10.5858/arpa.2012-0210-RA. Link to article on publisher's site
Archives of pathology and laboratory medicine
Zhou, Amy G; Owens, Christopher L.; Cosar, Ediz F.; and Jiang, Zhong, "Clinical implications of current developments in genitourinary pathology" (2013). University of Massachusetts Medical School Faculty Publications. 486.