Department of Medicine, Division of Infectious Diseases and Immunology
Infectious Disease | Public Health | Virology | Virus Diseases
Dengue virus (DENV) infections range from asymptomatic or mild illness to a severe and potentially life threatening disease, dengue hemorrhagic fever (DHF). DHF occurs in primary DENV infections during early infancy. A prospective clinical study of DENV infections during infancy was conducted in San Pablo, Philippines. We found that infants who developed DHF with a primary DENV infection had higher WHO weight-for-age z scores before and at the time of infection compared to infants with primary DENV infections who did not develop DHF. In addition, TLR 7/8-stimulated tumor necrosis factor-alpha (TNF-alpha) production from myeloid-derived cells was higher among well-nourished infants. Leptin augmented TLR 7/8-mediated TNF-alpha production in monocytes and decreased intracellular cAMP levels. Circulating leptin levels were elevated during early infancy and correlated with WHO weight-for-age z scores. Our data support a plausible hypothesis as to why well-nourished infants are at risk for developing DHF with their first DENV infection.
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Citation: PLoS One. 2014 Feb 12;9(2):e88944. doi: 10.1371/journal.pone.0088944. eCollection 2014.Link to article on publisher's site
Libraty, Daniel H.; Zhang, Lei; Woda, Marcia; Giaya, Krisanthi; Kathivu, Chido Loveness; Acosta, Luz P.; Tallo, Veronica; Segubre-Mercado, Edelwisa; Bautista, Analisa; Obcena, AnaMae; Brion, Job D.; and Capeding, Rosario Z., "Low adiposity during early infancy is associated with a low risk for developing dengue hemorrhagic fever: a preliminary model" (2014). University of Massachusetts Medical School Faculty Publications. 434.
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