Low adiposity during early infancy is associated with a low risk for developing dengue hemorrhagic fever: a preliminary model
Authors
Libraty, Daniel H.Zhang, Lei
Woda, Marcia
Giaya, Krisanthi
Kathivu, Chido Loveness
Acosta, Luz P.
Tallo, Veronica
Segubre-Mercado, Edelwisa
Bautista, Analisa
Obcena, AnaMae
Brion, Job D.
Capeding, Rosario Z.
UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyDocument Type
Journal ArticlePublication Date
2014-02-12
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Dengue virus (DENV) infections range from asymptomatic or mild illness to a severe and potentially life threatening disease, dengue hemorrhagic fever (DHF). DHF occurs in primary DENV infections during early infancy. A prospective clinical study of DENV infections during infancy was conducted in San Pablo, Philippines. We found that infants who developed DHF with a primary DENV infection had higher WHO weight-for-age z scores before and at the time of infection compared to infants with primary DENV infections who did not develop DHF. In addition, TLR 7/8-stimulated tumor necrosis factor-alpha (TNF-alpha) production from myeloid-derived cells was higher among well-nourished infants. Leptin augmented TLR 7/8-mediated TNF-alpha production in monocytes and decreased intracellular cAMP levels. Circulating leptin levels were elevated during early infancy and correlated with WHO weight-for-age z scores. Our data support a plausible hypothesis as to why well-nourished infants are at risk for developing DHF with their first DENV infection.Source
PLoS One. 2014 Feb 12;9(2):e88944. doi: 10.1371/journal.pone.0088944. eCollection 2014.Link to article on publisher's siteDOI
10.1371/journal.pone.0088944Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30190PubMed ID
24533162Related Resources
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© 2014 Libraty et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Distribution License
http://creativecommons.org/licenses/by/4.0/ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0088944
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Except where otherwise noted, this item's license is described as © 2014 Libraty et al. This is an open-access article distributed under the terms of the <a href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</a>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.