Department of Medicine, Division of Infectious Diseases and Immunology
Hemic and Lymphatic Diseases | Immunology and Infectious Disease | Virus Diseases
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infection caused by a novel Bunyavirus. Analysis on the dynamic changes of clinical, laboratory, and immunological abnormalities associated with SFTS in a concurrent study is lacking. Thirty-three SFTS patients were admitted to Jiangsu People's Hospital, Nanjing, China, and diagnosis was made based on the clinical symptoms and positive viral RNA detected by RT-PCR. Four patients deceased and twenty-nine survived. Blood samples were collected every other day between Day 5 and Day 15 from the onset of fever. Samples from healthy volunteers were used as normal controls. Peak viral RNA load, serum enzymes, IL-6, and IL-10 were significantly higher in deceased patients compared to survivors. Viral load, serum enzymes, and cytokines declined in survivors within 2 weeks from onset of fever. CD69+ T cells were elevated early after infection while HLA-DR+ and CTLA4+ T cells were elevated during the recovery phase of those who survived. High level SFTSV viral load was concurrently observed with reduced PLT, elevated serum enzymes, elevated pro-inflammatory and anti-inflammatory cytokines, and activation of CD69+ T cells. The degree and pattern of changes in these parameters may indicate the clinical outcome in SFTSV-infected patients.
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Citation:PLoS One. 2014 Mar 21;9(3):e91679. doi: 10.1371/journal.pone.0091679. eCollection 2014. Link to article on publisher's site
Li, Jun; Han, Yaping; Xing, Yiping; Li, Shuang; Kong, Lianhua; Zhang, Yongxiang; Zhang, Lili; Liu, Ning; Wang, Qian; Wang, Shixia; Lu, Shan; and Huang, Zuhu, "Concurrent measurement of dynamic changes in viral load, serum enzymes, T cell subsets, and cytokines in patients with severe fever with thrombocytopenia syndrome" (2014). University of Massachusetts Medical School Faculty Publications. 429.
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