University of Massachusetts Medical School Faculty Publications


Preclinical investigations for thrombectomy devices--does it translate to humans

UMMS Affiliation

Department of Radiology

Publication Date


Document Type



Angiography, Digital Subtraction; Animals; Cerebral Angiography; Cerebrovascular Circulation; Device Approval; Disease Models, Animal; Dogs; Female; Humans; Male; Microscopy, Electron, Scanning; Models, Anatomic; Safety; Stroke; Thrombectomy; United States; United States Food and Drug Administration


Cardiovascular Diseases | Nervous System Diseases | Neurology | Radiology | Surgical Procedures, Operative


Currently, most preclinical models to validate thrombectomy technologies have not directly translated to the clinical arena. Herein, we review our strategy that combines in vitro and in vivo modeling to assess thrombectomy device safety and efficacy quantitatively.

Rights and Permissions

Citation: Gounis MJ, Wakhloo AK, Chueh JY. Preclinical investigations for thrombectomy devices--does it translate to humans? Stroke. 2013 Jun;44(6 Suppl 1):S7-S10. doi: 10.1161/STROKEAHA.111.000692. Link to article on publisher's site

Related Resources

Link to Article in PubMed


Acute ischemic stroke, clot, embolic shower, preclinical modeling, recanalization, thrombectomy

Journal/Book/Conference Title

Stroke; a journal of cerebral circulation

PubMed ID