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UMass Chan Affiliations
Department of Microbiology and Physiological SystemsDocument Type
Journal ArticlePublication Date
2013-06-12Keywords
BacteriaDrug Resistance, Microbial
Fungi
*Stress, Physiological
Bacteria
Microbial Physiology
Pathology
Metadata
Show full item recordAbstract
All microorganisms are exposed to periodic stresses that inhibit growth. Many bacteria and fungi weather these periods by entering a hardy, nonreplicating state, often termed quiescence or dormancy. When this occurs during an infection, the resulting slowly growing pathogen is able to tolerate both immune insults and prolonged antibiotic exposure. While the stresses encountered in a free-living environment may differ from those imposed by host immunity, these growth-limiting conditions impose common pressures, and many of the corresponding microbial responses appear to be universal. In this review, we discuss the common features of these growth-limited states, which suggest new approaches for treating chronic infections such as tuberculosis.Source
Rittershaus ES, Baek SH, Sassetti CM. The normalcy of dormancy: common themes in microbial quiescence. Cell Host Microbe. 2013 Jun 12;13(6):643-51. doi:10.1016/j.chom.2013.05.012. Link to article on publisher's site
DOI
10.1016/j.chom.2013.05.012Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30156PubMed ID
23768489Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.chom.2013.05.012