Humanized mice for the study of infectious diseases
Program in Molecular Medicine
Medical Subject Headings
Animals; Communicable Diseases; Disease Models, Animal; Humans; Mice; Translational Medical Research
Immunology and Infectious Disease
Many of the pathogens that cause human infectious diseases do not infect rodents or other mammalian species. Small animal models that allow studies of the pathogenesis of these agents and evaluation of drug efficacy are critical for identifying ways to prevent and treat human infectious diseases. Immunodeficient mice engrafted with functional human cells and tissues, termed 'humanized' mice, represent a critical pre-clinical bridge for in vivo studies of human pathogens. Recent advances in the development of humanized mice have allowed in vivo studies of multiple human infectious agents providing novel insights into their pathogenesis that was otherwise not possible.
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Citation: Brehm MA, Jouvet N, Greiner DL, Shultz LD. Humanized mice for the study of infectious diseases. Curr Opin Immunol. 2013 Aug;25(4):428-35. doi:10.1016/j.coi.2013.05.012. Link to article on publisher's site
Brehm, Michael A.; Jouvet, Nathalie; Greiner, Dale L.; and Shultz, Leonard D., "Humanized mice for the study of infectious diseases" (2013). University of Massachusetts Medical School Faculty Publications. 383.