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Authors
Lin, HonghuangDolmatova, Elena V.
Morley, Michael P.
Lunetta, Kathryn L.
McManus, David D.
Magnani, Jared W.
Margulies, Kenneth B.
Hakonarson, Hakon
del Monte, Federica
Benjamin, Emelia J.
Cappola, Thomas P.
Ellinor, Patrick T.
Document Type
Journal ArticlePublication Date
2014-02-01Keywords
UMCCTS fundinggenetics
eQTL
gene expression
atrial tissues
Cardiology
Cardiovascular Diseases
Genetics and Genomics
Molecular Genetics
Tissues
Metadata
Show full item recordAbstract
BACKGROUND: The human left and right atria have different susceptibilities to develop atrial fibrillation (AF). However, the molecular events related to structural and functional changes that enhance AF susceptibility are still poorly understood. OBJECTIVE: The purpose of this study was to characterize gene expression and genetic variation in human atria. METHODS: We studied the gene expression profiles and genetic variations in 53 left atrial and 52 right atrial tissue samples collected from the Myocardial Applied Genomics Network (MAGNet) repository. The tissues were collected from heart failure patients undergoing transplantation and from unused organ donor hearts with normal ventricular function. Gene expression was profiled using the Affymetrix GeneChip Human Genome U133A Array. Genetic variation was profiled using the Affymetrix Genome-Wide Human SNP Array 6.0. RESULTS: We found that 109 genes were differentially expressed between left and right atrial tissues. A total of 187 and 259 significant cis-associations between transcript levels and genetic variants were identified in left and right atrial tissues, respectively. We also found that a single nucleotide polymorphism at a known AF locus, rs3740293, was associated with the expression of MYOZ1 in both left and right atrial tissues. CONCLUSION: We found a distinct transcriptional profile between the right and left atrium and extensive cis-associations between atrial transcripts and common genetic variants. Our results implicate MYOZ1 as the causative gene at the chromosome 10q22 locus for AFSource
Lin H, Dolmatova EV, Morley MP, Lunetta KL, McManus DD, Magnani JW, Margulies KB, Hakonarson H, del Monte F, Benjamin EJ, Cappola TP, Ellinor PT. Gene expression and genetic variation in human atria. Heart Rhythm. 2014 Feb;11(2):266-71. doi: 10.1016/j.hrthm.2013.10.051. Link to article on publisher's site
DOI
10.1016/j.hrthm.2013.10.051Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30107PubMed ID
24177373Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.hrthm.2013.10.051