Title

Performance of ZDOCK in CAPRI rounds 20-26

UMMS Affiliation

Program in Bioinformatics and Integrative Biology

Date

10-3-2013

Document Type

Article

Disciplines

Bioinformatics | Computational Biology

Abstract

We report the performance of our approaches for protein-protein docking and interface analysis in CAPRI rounds 20-26. At the core of our pipeline was the ZDOCK program for rigid-body protein-protein docking. We then reranked the ZDOCK predictions using the ZRANK or IRAD scoring functions, pruned and analyzed energy landscapes using clustering, and analyzed the docking results using our interface prediction approach RCF. When possible, we used biological information from the literature to apply constraints to the search space during or after the ZDOCK runs. For approximately half of the standard docking challenges we made at least one prediction that was acceptable or better. For the scoring challenges we made acceptable or better predictions for all but one target. This indicates that our scoring functions are generally able to select the correct binding mode. (c) Proteins 2013;. (c) 2013 Wiley Periodicals, Inc.

Rights and Permissions

Citation: Proteins. 2013 Oct 3. doi: 10.1002/prot.24432. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Keywords

Protein-protein docking. Protein-protein interaction, Complexes, ZRANK, IRAD