UMass Chan Affiliations
Program in Bioinformatics and Integrative BiologyDocument Type
Journal ArticlePublication Date
2013-10-03Keywords
Protein-protein docking. Protein-protein interactionComplexes
ZRANK
IRAD
Bioinformatics
Computational Biology
Metadata
Show full item recordAbstract
We report the performance of our approaches for protein-protein docking and interface analysis in CAPRI rounds 20-26. At the core of our pipeline was the ZDOCK program for rigid-body protein-protein docking. We then reranked the ZDOCK predictions using the ZRANK or IRAD scoring functions, pruned and analyzed energy landscapes using clustering, and analyzed the docking results using our interface prediction approach RCF. When possible, we used biological information from the literature to apply constraints to the search space during or after the ZDOCK runs. For approximately half of the standard docking challenges we made at least one prediction that was acceptable or better. For the scoring challenges we made acceptable or better predictions for all but one target. This indicates that our scoring functions are generally able to select the correct binding mode. (c) Proteins 2013;. (c) 2013 Wiley Periodicals, Inc.Source
Proteins. 2013 Oct 3. doi: 10.1002/prot.24432. Link to article on publisher's siteDOI
10.1002/prot.24432Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30025PubMed ID
24123140Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/prot.24432