Releasing the brakes on a chromatin-remodeling enzyme
Program in Molecular Medicine
Adenosine Triphosphate; Animals; Cell Cycle; Chromatin; *Chromatin Assembly and Disassembly; DNA; DNA Helicases; Histones; Humans; Nuclear Proteins; Nucleosomes; Promoter Regions, Genetic; Transcription, Genetic
Cell Biology | Molecular Biology | Structural Biology
Chromatin-remodeling enzymes use the energy from ATP hydrolysis to mobilize, disrupt or change the histone composition of nucleosomes, facilitating nearly every nuclear event. Two recent studies indicate that remodeling enzymes harness the power of an ancient constitutively active DNA translocase and that different remodeling enzymes may use specialized coupling domains that communicate the presence of nucleosomal epitopes to regulate translocase and remodeling activity.
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Citation: Nat Struct Mol Biol. 2013 Jan;20(1):5-7. doi: 10.1038/nsmb.2482. Link to article on publisher's site
Nature structural and molecular biology
Manning, Benjamin J. and Peterson, Craig L., "Releasing the brakes on a chromatin-remodeling enzyme" (2013). University of Massachusetts Medical School Faculty Publications. 241.