University of Massachusetts Medical School Faculty Publications

Title

Chemical exchange saturation transfer effect in blood

UMMS Affiliation

Department of Radiology

Date

5-9-2013

Document Type

Article

Medical Subject Headings

Magnetic Resonance Imaging; Blood

Disciplines

Diagnosis | Radiology

Abstract

PURPOSE: In this report, the feasibility of using blood as an agent for Chemical Exchange Saturation Transfer (CEST) effect is investigated.

METHODS: The CEST effect of porcine blood samples was investigated on a 3.0 T MRI scanner using various power levels and on a 14.1 T NMR spectrometer. As a proof-of-concept that CEST can be used to image blood in vivo, the technique was applied in two locations of healthy human volunteers, namely, the femoral artery and the M1-segment of the middle cerebral artery.

RESULTS: The blood sample experiments showed that maximum CEST Magnetization Transfer Ratio asymmetry (MTRasym ) values of approximately 12% were achieved, with likely contributions from multiple blood components. These findings were confirmed during the in vivo experiments where CEST signal of blood was clearly greater than surrounding muscular (2%) and brain tissue (3%).

CONCLUSION: Ex vivo and in vivo results show that blood is a suitable CEST agent that generates sufficient CEST contrast relative to surrounding tissue.

Rights and Permissions

Citation: Magn Reson Med. 2013 May 9. doi: 10.1002/mrm.24770. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

23661508