University of Massachusetts Medical School Faculty Publications


The role of autophagy in Drosophila metamorphosis

UMMS Affiliation

Department of Cancer Biology

Publication Date


Document Type



Autophagy; Drosophila; Metamorphosis, Biological


Developmental Biology


Macroautophagy (autophagy) is a conserved catabolic process that targets cytoplasmic components to lysosomes for degradation. Autophagy is required for cellular homeostasis and cell survival in response to starvation and stress, and paradoxically, it also plays a role in programmed cell death during development. The mechanisms that regulate the relationship between autophagy, cell survival, and cell death are poorly understood. Here we review research in Drosophila that has provided insights into the regulation of autophagy by steroid hormones and nutrient restriction and discuss how autophagy influences cell growth, nutrient utilization, cell survival, and cell death.

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Citation: Curr Top Dev Biol. 2013;103:101-25. doi: 10.1016/B978-0-12-385979-2.00004-6. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Current topics in developmental biology

PubMed ID