University of Massachusetts Medical School Faculty Publications

Title

Protein translocation across the rough endoplasmic reticulum

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Date

2-1-2013

Document Type

Article

Medical Subject Headings

Endoplasmic Reticulum, Rough; Protein Transport

Disciplines

Biochemistry, Biophysics, and Structural Biology | Cell Biology

Abstract

The rough endoplasmic reticulum is a major site of protein biosynthesis in all eukaryotic cells, serving as the entry point for the secretory pathway and as the initial integration site for the majority of cellular integral membrane proteins. The core components of the protein translocation machinery have been identified, and high-resolution structures of the targeting components and the transport channel have been obtained. Research in this area is now focused on obtaining a better understanding of the molecular mechanism of protein translocation and membrane protein integration.

Comments

Citation: Cold Spring Harb Perspect Biol. 2013 Feb 1;5(2). pii: a013342. doi: 10.1101/cshperspect.a013342. Link to article on publisher's site

Related Resources

Link to Article in PubMed