University of Massachusetts Medical School Faculty Publications


Protein translocation across the rough endoplasmic reticulum

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology



Document Type


Medical Subject Headings

Endoplasmic Reticulum, Rough; Protein Transport


Biochemistry, Biophysics, and Structural Biology | Cell Biology


The rough endoplasmic reticulum is a major site of protein biosynthesis in all eukaryotic cells, serving as the entry point for the secretory pathway and as the initial integration site for the majority of cellular integral membrane proteins. The core components of the protein translocation machinery have been identified, and high-resolution structures of the targeting components and the transport channel have been obtained. Research in this area is now focused on obtaining a better understanding of the molecular mechanism of protein translocation and membrane protein integration.


Citation: Cold Spring Harb Perspect Biol. 2013 Feb 1;5(2). pii: a013342. doi: 10.1101/cshperspect.a013342. Link to article on publisher's site

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Link to Article in PubMed

PubMed ID