University of Massachusetts Medical School Faculty Publications

Title

Resurrecting remnants: the lives of post-mitotic midbodies

UMMS Affiliation

Program in Molecular Medicine

Publication Date

3-11-2013

Document Type

Article

Subjects

Cytokinesis

Disciplines

Cell and Developmental Biology | Cell Biology | Cellular and Molecular Physiology

Abstract

Around a century ago, the midbody (MB) was described as a structural assembly within the intercellular bridge during cytokinesis that served to connect the two future daughter cells. The MB has become the focus of intense investigation through the identification of a growing number of diverse cellular and molecular pathways that localize to the MB and contribute to its cytokinetic functions, ranging from selective vesicle trafficking and regulated microtubule (MT), actin, and endosomal sorting complex required for transport (ESCRT) filament assembly and disassembly to post-translational modification, such as ubiquitination. More recent studies have revealed new and unexpected functions of MBs in post-mitotic cells. In this review, we provide a historical perspective, discuss exciting new roles for MBs beyond their cytokinetic function, and speculate on their potential contributions to pluripotency.

Rights and Permissions

Citation: Trends Cell Biol. 2013 Mar;23(3):118-28. doi: 10.1016/j.tcb.2012.10.012. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Trends in cell biology

PubMed ID

23245592