Program in Molecular Medicine
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Medical Subject Headings
Nuclear Envelope; Nuclear Pore
Molecular Biology | Molecular Genetics
The nuclear envelope forms a cocoon that surrounds the cellular genome keeping it out of harm's way and can be utilized by the cell as a means of functionally regulating chromatin structure and gene expression. At the same time, this double-layered membrane system constitutes a formidable obstacle to the unimpeded flow of genetic information between the genome and the rest of the cell. The nuclear pore has been long considered the sole passageway between nucleus and cytoplasm. A new report challenges this view and proposes a novel mechanism by which RNA transcripts destined for localized translation in highly polarized cell types, cross both inner and outer nuclear envelope membranes and reach the cytoplasm without utilizing the nuclear pore route.
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Citation: Nucleus. 2013 Mar-Apr;4(2):95-9. doi: 10.4161/nucl.24237. Epub 2013 Mar 1. Link to article on publisher's site
Strambio-De-Castilla, Caterina, "Jumping over the fence: RNA nuclear export revisited" (2013). University of Massachusetts Medical School Faculty Publications. 172.