University of Massachusetts Medical School Faculty Publications

Title

Molecular basis of DNA recognition in the immune system

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date

3-1-2013

Document Type

Article

Subjects

Animals; Autoimmunity; Bacteria; Bacterial Infections; Cytokines; DNA, Bacterial; Exodeoxyribonucleases; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Immune System; *Immunity, Innate; Inflammasomes; Inflammation; Signal Transduction

Disciplines

Immunity | Immunology and Infectious Disease

Abstract

Recognition of microbial nucleic acids is one strategy by which mammalian hosts respond to infectious agents. Intracellular DNA that is introduced into cells during infection elicits potent inflammatory responses by triggering the induction of antiviral type I IFNs and the maturation and secretion of inflammatory cytokines, such as TNF-alpha, IL-1beta, and IL-18. In addition, if nucleases, such as DNase II or DNase III (Trex1), fail to clear self-DNA, accumulated DNA gains access to intracellular compartments where it drives inflammatory responses leading to autoimmune disease. In this review, we discuss a rapidly evolving view of how cytosolic DNA-sensing machineries coordinate antimicrobial immunity and, if unchecked, lead to autoimmune disease.

Comments

Citation: J Immunol. 2013 Mar 1;190(5):1911-8. doi: 10.4049/jimmunol.1203162. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Journal of immunology (Baltimore, Md. : 1950)

PubMed ID

23417527