UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyDocument Type
Journal ArticlePublication Date
2013-03-01Keywords
AnimalsAutoimmunity
Bacteria
Bacterial Infections
Cytokines
DNA, Bacterial
Exodeoxyribonucleases
Gene Expression Regulation
Host-Pathogen Interactions
Humans
Immune System
*Immunity, Innate
Inflammasomes
Inflammation
Signal Transduction
Immunity
Immunology and Infectious Disease
Metadata
Show full item recordAbstract
Recognition of microbial nucleic acids is one strategy by which mammalian hosts respond to infectious agents. Intracellular DNA that is introduced into cells during infection elicits potent inflammatory responses by triggering the induction of antiviral type I IFNs and the maturation and secretion of inflammatory cytokines, such as TNF-alpha, IL-1beta, and IL-18. In addition, if nucleases, such as DNase II or DNase III (Trex1), fail to clear self-DNA, accumulated DNA gains access to intracellular compartments where it drives inflammatory responses leading to autoimmune disease. In this review, we discuss a rapidly evolving view of how cytosolic DNA-sensing machineries coordinate antimicrobial immunity and, if unchecked, lead to autoimmune disease.Source
J Immunol. 2013 Mar 1;190(5):1911-8. doi: 10.4049/jimmunol.1203162. Link to article on publisher's siteDOI
10.4049/jimmunol.1203162Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29411PubMed ID
23417527Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.4049/jimmunol.1203162