University of Massachusetts Medical School Faculty Publications

Title

Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus

UMMS Affiliation

Department of Medicine, Division of Preventive and Behavioral Medicine

Publication Date

9-2-2016

Document Type

Article

Disciplines

Immunology and Infectious Disease | Virus Diseases

Abstract

HIV-1-specific broadly neutralizing antibodies (bNAbs) can protect rhesus monkeys against simian-human immunodeficiency virus (SHIV) challenge. However, the site of antibody interception of virus and the mechanism of antibody-mediated protection remain unclear. We administered a fully protective dose of the bNAb PGT121 to rhesus monkeys and challenged them intravaginally with SHIV-SF162P3. In PGT121-treated animals, we detected low levels of viral RNA and viral DNA in distal tissues for seven days following challenge. Viral RNA-positive tissues showed transcriptomic changes indicative of innate immune activation, and cells from these tissues initiated infection after adoptive transfer into naive hosts. These data demonstrate that bNAb-mediated protection against a mucosal virus challenge can involve clearance of infectious virus in distal tissues.

Rights and Permissions

Citation: Science. 2016 Sep 2;353(6303):1045-1049. Epub 2016 Aug 18. Link to article on publisher's site

Comments

Full list of authors omitted for brevity. For full list see article.

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Science (New York, N.Y.)

PubMed ID

27540005