Endocytic transport and cytokinesis: from regulation of the cytoskeleton to midbody inheritance
Program in Molecular Medicine
Abscission is the last step of cytokinesis that leads to the physical separation of two daughter cells. An emerging picture is that abscission is a complex event that relies on changes in both lipid composition and cytoskeletal dynamics. These subcellular processes lead to the establishment of the abscission site and recruitment of the ESCRT-III protein complex to mediate the final separation event. It has become apparent that endocytic transport to the cleavage furrow during late cytokinesis mediates and coordinates lipid and cytoskeleton dynamics, thus playing a key role in abscission. Furthermore, new evidence suggests that endosomes may have additional roles in post-mitotic cellular events such as midbody inheritance and degradation. Here, we highlight recent findings regarding the function of these endosomes in the regulation of cell division.
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Citation: Trends Cell Biol. 2013 Jul;23(7):319-27. doi: 10.1016/j.tcb.2013.02.003. Link to article on publisher's site
endosome, phosphoinositide, Rho kinase, ESCRT-III complex
Schiel, John; Childs, Carly; and Prekeris, Rytis, "Endocytic transport and cytokinesis: from regulation of the cytoskeleton to midbody inheritance" (2013). University of Massachusetts Medical School Faculty Publications. 136.