University of Massachusetts Medical School Faculty Publications


Regulation of postsynaptic retrograde signaling by presynaptic exosome release

UMMS Affiliation

Department of Neurobiology; Budnik Lab; Yoshihara Lab; Graduate School of Biomedical Sciences, Neuroscience Program

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Animals; Animals, Genetically Modified; Drosophila; Drosophila Proteins; Exosomes; Neuromuscular Junction; Presynaptic Terminals; Signal Transduction; Synapses; Synaptic Potentials; Synaptotagmins


Developmental Neuroscience | Molecular and Cellular Neuroscience


Retrograde signals from postsynaptic targets are critical during development and plasticity of synaptic connections. These signals serve to adjust the activity of presynaptic cells according to postsynaptic cell outputs and to maintain synaptic function within a dynamic range. Despite their importance, the mechanisms that trigger the release of retrograde signals and the role of presynaptic cells in this signaling event are unknown. Here we show that a retrograde signal mediated by Synaptotagmin 4 (Syt4) is transmitted to the postsynaptic cell through anterograde delivery of Syt4 via exosomes. Thus, by transferring an essential component of retrograde signaling through exosomes, presynaptic cells enable retrograde signaling.

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Citation: Neuron. 2013 Mar 20;77(6):1039-46. doi: 10.1016/j.neuron.2013.01.013. Link to article on publisher's site


Authors Korkut, Li, and Ashley are doctoral students in the Neuroscience Program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.

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