Outcomes Among Older Patients Receiving Implantable Cardioverter-Defibrillators for Secondary Prevention: From the NCDR ICD Registry
Department of Medicine, Division of Cardiovascular Medicine
Cardiology | Geriatrics
BACKGROUND: Clinical trials of implantable cardioverter-defibrillators (ICDs) for secondary prevention of sudden cardiac death were conducted nearly 2 decades ago and enrolled few older patients. OBJECTIVES: This study assessed morbidity and mortality of older patients receiving ICDs for secondary prevention in contemporary clinical practice. METHODS: We identified 12,420 Medicare beneficiaries from the National Cardiovascular Data Registry ICD Registry undergoing first-time secondary prevention ICD implantation between 2006 and 2009 in 956 U.S. hospitals. Risks of death, hospitalization, and admission to a skilled nursing facility (SNF) were assessed over 2 years in age strata (65 to 69, 70 to 74, 75 to 79, and > /=80 years of age) using Medicare claims. The adjusted association between age and outcomes was evaluated using multivariable models. RESULTS: The mean age was 75 years at the time of implantation; 25.3% were <70 years of age and>25.7% were > /=80 years of age. Overall, the risk of death at 2 years was 21.8%, ranging from 14.7% among those <70 years of age to>28.9% among those > /=80 years of age (adjusted risk ratio [aRR]: 2.01; 95% confidence interval [CI]: 1.85 to 2.33; p for trend <0.001). The cumulative incidence of hospitalizations was 65.4%, ranging from 60.5% in those <70 years of age to 71.5% in those > /=80 years of age (aRR: 1.27; 95% CI: 1.19 to 1.36; p for trend <0.001). The cumulative incidence of admission to a SNF ranged from 13.1% among those <70 years of age to 31.9% among those > /=80 years of age (aRR: 2.67; 95% CI: 2.37 to 3.01; p for trend <0.001); SNF admission risk was highest in the first 30 days. CONCLUSIONS: Almost 1 in 5 older patients receiving a secondary prevention ICD survives at least 2 years. High hospitalization and SNF admission rates, particularly among the oldest patients, identify substantial care needs after device implantation.
arrhythmia, elderly, electrophysiology
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Citation: J Am Coll Cardiol. 2017 Jan 24;69(3):265-274. doi: 10.1016/j.jacc.2016.10.062. Link to article on publisher's site
Journal of the American College of Cardiology
Betz, Jarrod K.; Katz, David F.; Peterson, Pamela N.; Borne, Ryan T.; Al-Khatib, Sana M.; Wang, Yongfei; Hansen, Carolina Malta; McManus, David D.; Mathew, Jehu S.; and Masoudi, Frederick A., "Outcomes Among Older Patients Receiving Implantable Cardioverter-Defibrillators for Secondary Prevention: From the NCDR ICD Registry" (2017). University of Massachusetts Medical School Faculty Publications. 1303.