Drosophilosophical: Re-thinking Adaptive Immunity in the Fly
Division of Infectious Diseases and Immunology, Department of Medicine
For decades, flies have been a model for innate immunity. In this issue of Cell, Tassetto et al. describe a mechanism for antiviral RNAi spreading that parallels mammalian adaptive immunity through reverse-transcribed vDNA circles and the systemic dissemination of small-RNA-containing exosomes.
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Citation: Cell. 2017 Apr 6;169(2):188-190. doi: 10.1016/j.cell.2017.03.032. Link to article on publisher's site
West, Cara C. and Silverman, Neal S., "Drosophilosophical: Re-thinking Adaptive Immunity in the Fly" (2017). University of Massachusetts Medical School Faculty Publications. 1290.