Translational control of cell growth and malignancy by the CPEBs
Program in Molecular Medicine
Medical Subject Headings
Animals; Cell Aging; Cell Cycle; Cell Proliferation; Humans; *Neoplasms; Protein Biosynthesis; RNA, Messenger; RNA-Binding Proteins; Transcription Factors; mRNA Cleavage and Polyadenylation Factors
Cancer Biology | Cell Biology | Molecular Biology | Molecular genetics
The cytoplasmic polyadenylation element binding proteins (CPEBs) associate with specific sequences in mRNA 3' untranslated regions to promote translation. They do so by inducing cytoplasmic polyadenylation, which requires specialized poly(A) polymerases. Aberrant expression of these proteins correlates with certain types of cancer, indicating that cytoplasmic RNA 3' end processing is important in the control of growth. Several CPEB-regulated mRNAs govern cell cycle progression, regulate senescence, establish cell polarity, and promote tumorigenesis and metastasis. In this Opinion article, we discuss the emerging evidence that indicates a key role for the CPEBs in cancer biology.
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Citation: Nat Rev Cancer. 2013 Apr;13(4):283-90. doi: 10.1038/nrc3485. Epub 2013 Feb 28. Link to article on publisher's site