University of Massachusetts Medical School Faculty Publications

Title

Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice

UMMS Affiliation

Department of Medicine, Division of Gastroenterology; Graduate School of Biomedical Sciences, Translational Science Program; UMass Metabolic Network

Date

3-27-2017

Document Type

Article

Disciplines

Cell Biology | Cellular and Molecular Physiology | Digestive System Diseases | Gastroenterology | Hepatology

Abstract

BACKGROUND and AIMS: Inflammation and impaired hepatocyte regeneration contribute to liver failure in alcoholic hepatitis (AH). Interleukin (IL)-1 is a key inflammatory cytokine in the pathobiology of AH. The role of IL-1 in liver regeneration in the recovery phase of alcohol-induced liver injury is unknown.

METHODS: Here we tested IL-1 receptor antagonist to block IL-1 signaling in a mouse model of acute-on-chronic liver injury on liver inflammation and hepatocyte regeneration in AH.

RESULTS: We observed that inhibition of IL-1 signaling decreased liver inflammation, neutrophil infiltration, enhanced regeneration of hepatocytes, and resulted in increased rate of recovery from liver injury in AH.

CONCLUSION: Our novel findings suggest that IL-1 drives sustained liver inflammation and impaired hepatocyte regeneration even after cessation of ethanol exposure.

Rights and Permissions

Citation: Liver Int. 2017 Mar 26. doi: 10.1111/liv.13430. Link to article on publisher's site

Comments

First author Arvin Iracheta-Vellve is a doctoral student in the Translational Science program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.

Related Resources

Link to Article in PubMed

Keywords

alcoholic liver disease, interleukin 1, interleukin 1 receptor antagonist, liver regeneration

PubMed ID

28345165