University of Massachusetts Medical School Faculty Publications

Title

Gadolinium-Induced Fibrosis

UMMS Affiliation

Division of Rheumatology, Department of Medicine

Date

1-1-2016

Document Type

Article

Disciplines

Rheumatology | Skin and Connective Tissue Diseases

Abstract

Gadolinium-based contrast agents (GBCAs), once believed to be safe for patients with renal disease, have been strongly associated with nephrogenic systemic fibrosis (NSF), a severe systemic fibrosing disorder that predominantly afflicts individuals with advanced renal dysfunction. We provide a historical perspective on the appearance and disappearance of NSF, including its initial recognition as a discrete clinical entity, its association with GBCA exposure, and the data supporting a causative relationship between GBCA exposure and NSF. On the basis of this body of evidence, we propose that the name gadolinium-induced fibrosis (GIF) more accurately reflects the totality of knowledge regarding this disease. Use of high-risk GBCAs, such as formulated gadodiamide, should be avoided in patients with renal disease. Restriction of GBCA use in this population has almost completely eradicated new cases of this debilitating condition. Emerging antifibrotic therapies may be useful for patients who suffer from GIF.

Rights and Permissions

Citation: Annu Rev Med. 2016;67:273-91. doi: 10.1146/annurev-med-063014-124936. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Keywords

Gd, chronic kidney disease, fibrosing disorders, gadolinium-based contrast agents, magnetic resonance imaging, nephrogenic systemic fibrosis

PubMed ID

26768242