An exploratory study of therapeutic misconception among incarcerated clinical trial participants
Department of Psychiatry; Systems and Psychosocial Advances Research Center
Bioethics and Medical Ethics
BACKGROUND: Therapeutic misconception, the misunderstanding of differences between research and clinical care, is widely prevalent among non-incarcerated trial participants. Yet little attention has been paid to its presence among individuals who participate in research while incarcerated.
METHODS: This study examined the extent to which seventy-two incarcerated individuals may experience therapeutic misconception about their participation in one of six clinical trials, and its correlation with participant characteristics and potential influences on research participation.
RESULTS: On average, participants endorsed 70% of items suggestive of therapeutic misconception. The tendency toward therapeutic misconception was significantly higher among: African Americans and Latinos compared to Whites; older and less educated participants; enrollment in a substance abuse-related trial; and correlated with a belief that the trial was the only way to obtain needed treatment.
CONCLUSIONS: Therapeutic misconception may be particularly high among select incarcerated individuals and is associated with a perceived lack of treatment options. Further examination of therapeutic misconception among incarcerated research participants is needed.
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Citation: AJOB Empir Bioeth. 2016;7(1):24-30. Epub 2015 Jun 24. Link to article on publisher's site
incarceration, informed consent, prisoners, therapeutic misconception, vulnerable populations
AJOB empirical bioethics
Christopher, Paul P.; Stein, Michael D.; Springer, Sandra A.; Rich, Josiah D.; Johnson, Jennifer E.; and Lidz, Charles W., "An exploratory study of therapeutic misconception among incarcerated clinical trial participants" (2016). University of Massachusetts Medical School Faculty Publications. 1176.