Immunology. An RNA twist to T(H)17 cells
Program in Innate Immunity; Division of Infectious Diseases and Immunology, Department of Medicine
Immunology and Infectious Disease
T helper lymphocytes play essential roles in the adaptive immune system. They come in distinct types defined by unique transcriptional programs that control their development and functions. Among these, T helper 17 (TH17) cells are important in protecting mucosal surfaces against fungal and bacterial infections. In addition, TH17 cells contribute to the pathogenesis of multiple autoimmune diseases (1). A recent study (2) adds yet another layer of complexity to the biology of these complex cells—an RNA helicase and a long noncoding RNA (lncRNA) that act together to control their effector functions.
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Citation: Science. 2016 Mar 4;351(6277):1032. doi: 10.1126/science.aaf4691. Link to article on publisher's site
Atianand, Maninjay K. and Fitzgerald, Katherine A., "Immunology. An RNA twist to T(H)17 cells" (2016). University of Massachusetts Medical School Faculty Publications. 1150.