No effect of adjunctive, repeated-dose intranasal insulin treatment on psychopathology and cognition in patients with schizophrenia
Authors
Fan, XiaoduoLiu, Emily
Freudenreich, Oliver
Copeland, Paul
Hayden, Douglas
Ghebremichael, Musie
Cohen, Bruce M.
Ongur, Dost
Goff, Donald C.
Henderson, David C.
UMass Chan Affiliations
Department of PsychiatryDocument Type
Journal ArticlePublication Date
2013-04-01Keywords
SchizophreniaInsulin
Cognition
Psychopathology
Mental and Social Health
Mental Disorders
Psychiatry and Psychology
Therapeutics
Metadata
Show full item recordAbstract
OBJECTIVE: This study examined the effect of adjunctive intranasal insulin therapy on psychopathology and cognition in patients with schizophrenia. METHODS: Each subject had a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnosis of schizophrenia or schizoaffective disorder and been on stable antipsychotics for at least 1 month. In an 8-week randomized, double-blind, placebo-controlled study, subjects received either intranasal insulin (40 IU 4 times per day) or placebo. Psychopathology was assessed using the Positive and Negative Syndrome Scale and the Scale for Assessment of Negative Symptoms. A neuropsychological battery was used to assess cognitive performance. The assessment for psychopathology and cognition was conducted at baseline, week 4, and week 8. RESULTS: A total of 45 subjects were enrolled in the study (21 in the insulin group and 24 in the placebo group). The mixed model analysis showed that there were no significant differences between the 2 groups at week 8 on various psychopathology and cognitive measures (P > 0.1). CONCLUSIONS: Adjunctive therapy with intranasal insulin did not seem to be beneficial in improving schizophrenia symptoms or cognition in the present study. The implications for future studies were discussed.Source
J Clin Psychopharmacol. 2013 Apr;33(2):226-30. doi: 10.1097/JCP.0b013e31828701d0. Link to article on publisher's siteDOI
10.1097/JCP.0b013e31828701d0Permanent Link to this Item
http://hdl.handle.net/20.500.14038/28909PubMed ID
23422397Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1097/JCP.0b013e31828701d0