Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine
Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network
Cancer Biology | Nanotechnology
Metastasis, drug resistance and recurrence in cancer are regulated by the tumor microenvironment. This review describes recent advances in understanding how cancer cells respond to extracellular environmental cues via integrins, how to build engineered microenvironments to study these interactions in vitro and how nanomaterials can be used to detect and target tumor microenvironments.
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Citation: Drug Discov Today. 2016 Sep;21(9):1489-94. doi: 10.1016/j.drudis.2016.05.011. Epub 2016 May 26. Link to article on publisher's site
Drug discovery today
Yoshii, Tatsuyuki; Geng, Yingying; Peyton, Shelly; Mercurio, Arthur M.; and Rotello, Vincent M., "Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine" (2016). University of Massachusetts Medical School Faculty Publications. 1103.