University of Massachusetts Medical School Faculty Publications


Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine

UMMS Affiliation

Department of Molecular, Cell and Cancer Biology; UMass Metabolic Network

Publication Date


Document Type



Cancer Biology | Nanotechnology


Metastasis, drug resistance and recurrence in cancer are regulated by the tumor microenvironment. This review describes recent advances in understanding how cancer cells respond to extracellular environmental cues via integrins, how to build engineered microenvironments to study these interactions in vitro and how nanomaterials can be used to detect and target tumor microenvironments.

Rights and Permissions

Citation: Drug Discov Today. 2016 Sep;21(9):1489-94. doi: 10.1016/j.drudis.2016.05.011. Epub 2016 May 26. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Drug discovery today

PubMed ID