Relation of longitudinal changes in body mass index with atherosclerotic cardiovascular disease risk scores in middle-aged black and white adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Department of Quantitative Health Sciences
Cardiovascular Diseases | Clinical Epidemiology | Epidemiology
PURPOSE: We assessed whether longitudinal changes in body mass index (BMI) are positively associated with changes in 10-year American College of Cardiology/American Heart Association atherosclerotic cardiovascular disease (ASCVD) risk scores in middle-aged blacks compared to whites.
METHODS: Data were from 1691 participants enrolled in the Coronary Artery Risk Development in Young Adults Study aged 40 years or more in 2000-2001, who had follow-up examinations 5 and 10 years later.
RESULTS: The prevalence of obesity increased from 32.3% in 2000-2001 (mean age: 42.8 years) to 41.7% in 2010-2011, higher in blacks than whites. The corresponding change in 10-year ASCVD risk was significantly higher for blacks (men: 4.5%-9.6%, women: 1.7%-5.0%) than whites (men: 2.4%-5.2%, women: 0.7%-1.6%). In 2010-2011, 57.5% of black men had ASCVD risk scores of 7.5% or more compared to white men (14.7%), black women (17.4%), and white women (1.6%). Although BMI trends were positively associated with 10-year change in ASCVD risk scores (0.07% per 1 kg/m(2) increase), it explained very little variance in risk score trends in all race-sex groups.
CONCLUSIONS: In middle-aged adults, longitudinal changes in BMI had little independent influence on changes in 10-year ASCVD risk scores as its effect may be largely mediated through ASCVD risk factors already accounted for in the risk score.
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Citation: Ann Epidemiol. 2016 Aug;26(8):521-6. doi: 10.1016/j.annepidem.2016.06.008. Epub 2016 Jun 17. Link to article on publisher's site
Cardiovascular disease, Obesity, Risk prediction
Appiah, Duke; Schreiner, Pamela J.; Durant, Raegan W.; Kiefe, Catarina I.; Loria, Catherine M.; Lewis, Cora E.; Williams, O. Dale; Person, Sharina D.; and Sidney, Stephen, "Relation of longitudinal changes in body mass index with atherosclerotic cardiovascular disease risk scores in middle-aged black and white adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study" (2016). University of Massachusetts Medical School Faculty Publications. 1084.