University of Massachusetts Medical School Faculty Publications

Title

GBPs take AIM at Francisella

UMMS Affiliation

Program in Innate Immunity; Department of Medicine, Division of Infectious Diseases and Immunology

Date

5-1-2015

Document Type

Article

Disciplines

Immunity

Abstract

Guanylate-binding proteins (GBPs) induced by type I interferon signaling cause lysis ofFrancisella bacteria that have reached the host-cell cytosol. The liberated bacterial DNA is then sensed by the cytosolic AIM2 inflammasome, which activates caspase-1 and leads to pyroptotic cell death.

Rights and Permissions

Citation: Nat Immunol. 2015 May;16(5):443-4. doi: 10.1038/ni.3144. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

25898190