GBPs take AIM at Francisella
Program in Innate Immunity; Department of Medicine, Division of Infectious Diseases and Immunology
Guanylate-binding proteins (GBPs) induced by type I interferon signaling cause lysis ofFrancisella bacteria that have reached the host-cell cytosol. The liberated bacterial DNA is then sensed by the cytosolic AIM2 inflammasome, which activates caspase-1 and leads to pyroptotic cell death.
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Citation: Nat Immunol. 2015 May;16(5):443-4. doi: 10.1038/ni.3144. Link to article on publisher's site
Fitzgerald, Katherine A. and Rathinam, Vijay A. K., "GBPs take AIM at Francisella" (2015). University of Massachusetts Medical School Faculty Publications. 1001.