UMMS Affiliation

Department of Medicine, Division of Dermatology

Date

4-25-2013

Document Type

Article

Medical Subject Headings

Amines; Antidepressive Agents, Tricyclic; Behavior Therapy; Chronic Disease; Cyclohexanecarboxylic Acids; Emollients; Excitatory Amino Acid Antagonists; Histamine Antagonists; Humans; Male; Mianserin; Middle Aged; Pruritus; gamma-Aminobutyric Acid

Disciplines

Dermatology | Skin and Connective Tissue Diseases

Abstract

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors' clinical recommendations. Case: An otherwise healthy 55-year-old man reports that he has been itchy all over for 6 months. The itch interferes with falling asleep and wakes him repeatedly during the night. Initially, there was no rash, but during the past 4 months, itchy nodules and plaques have developed on his back, arms, and legs. Treatment with sedating and nonsedating oral antihistamines and topical glucocorticoids has had no effect. How would you evaluate and manage this case?

Rights and Permissions

Citation: N Engl J Med. 2013 Apr 25;368(17):1625-34. doi: 10.1056/NEJMcp1208814. Link to article on publisher's site

Comments

Publisher PDF posted as allowed by the publisher's author rights policy at http://www.nejm.org/page/author-center/permissions.

Related Resources

Link to Article in PubMed

PubMed ID

23614588

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