Title

Pigmented basal cell carcinoma: investigation of 70 cases

UMMS Affiliation

Department of Medicine, Division of Dermatology

Date

7-1-1992

Document Type

Article

Medical Subject Headings

Biopsy; Carcinoma, Basal Cell; Humans; Melanins; Melanocytes; Skin; Skin Neoplasms; Staining and Labeling

Disciplines

Dermatology | Neoplasms | Skin and Connective Tissue Diseases

Abstract

BACKGROUND: Pigmented basal cell carcinoma (PBCC) is a clinical and histologic variant of BCC.

OBJECTIVE: Our purpose was to identify the histologic subtypes of BCC that were most often associated with pigment and to determine whether this correlated with outcome after excision.

METHODS: A series of PBCC was identified and the histologic subtype noted. Margins of all excisions were examined for residual tumor. These results were then compared with a series of nonpigmented BCCs.

RESULTS: In a series of 1039 consecutive BCCs, 70 (6.7%) contained pigment. The histologic growth pattern most frequently associated with pigment was the nodular/micronodular pattern (12.4%) followed by the nodular (7.7%), superficial (7.2%), micronodular (4.0%), and the nodular/micronodular/infiltrative (3.4%) patterns. Margins were examined for evidence of residual tumor in the 40 cases that were excised. In only one case (2.5%) was the margin positive for tumor. This was statistically significant (p less than 0.05) compared with 388 excisions of nonpigmented BCCs with comparable growth patterns in which 69 (17.7%) showed positive margins.

CONCLUSION: PBCC, as a clinical variant, is more frequently excised with adequate margins than are tumors of comparable histologic subtypes that do not contain pigment.

Comments

Citation: J Am Acad Dermatol. 1992 Jul;27(1):74-8. doi:10.1016/0190-9622(92)70160-H

At the time of publication, Mary E. Maloney was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed