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UMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
2009-01-23Keywords
BiochemistryCell Biology
Cellular and Molecular Physiology
Digestive System Diseases
Molecular Biology
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Show full item recordAbstract
The c-Jun NH(2)-terminal kinase (JNK) signaling pathway has been implicated in the development of tumor necrosis factor (TNF)-dependent hepatitis. JNK may play a critical role in hepatocytes during TNF-stimulated cell death in vivo. To test this hypothesis, we examined the phenotype of mice with compound disruption of the Jnk1 and Jnk2 genes. Mice with loss of JNK1/2 expression in hepatocytes exhibited no defects in the development of hepatitis compared with control mice, whereas mice with loss of JNK1/2 in the hematopoietic compartment exhibited a profound defect in hepatitis that was associated with markedly reduced expression of TNF-alpha. These data indicate that JNK is required for TNF-alpha expression but not for TNF-alpha-stimulated death of hepatocytes. Indeed, TNF-alpha induced similar hepatic damage in both mice with hepatocyte-specific JNK1/2 deficiency and control mice. These observations confirm a role for JNK in the development of hepatitis but identify hematopoietic cells as the site of the essential function of JNK.Source
Cell. 2009 Jan 23;136(2):249-60. doi: 10.1016/j.cell.2008.11.017. Link to article on publisher's site
DOI
10.1016/j.cell.2008.11.017Permanent Link to this Item
http://hdl.handle.net/20.500.14038/28349PubMed ID
19167327Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.cell.2008.11.017