TNF and MAP kinase signalling pathways

UMMS Affiliation

Program in Molecular Medicine



Document Type


Medical Subject Headings

Animals; Humans; *MAP Kinase Signaling System; Tumor Necrosis Factor-alpha


Biochemistry | Cell Biology | Cellular and Molecular Physiology | Molecular Biology


The binding of tumour necrosis factor alpha (TNFalpha) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun NH2-terminal kinases (JNKs); and the p38 MAP kinases. These MAP kinase signalling pathways induce a secondary response by increasing the expression of several inflammatory cytokines (including TNFalpha) that contribute to the biological activity of TNFalpha. MAP kinases therefore function both upstream and down-stream of signalling by TNFalpha receptors. Here we review mechanisms that mediate these actions of MAP kinases during the response to TNFalpha.

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Citation: Semin Immunol. 2014 Jun;26(3):237-45. doi: 10.1016/j.smim.2014.02.009. Epub 2014 Mar 16. Link to article on publisher's site

Related Resources

Link to Article in PubMed


ERK, JNK, MAP kinase, TNF, p38 MAP kinase

PubMed ID