TNF and MAP kinase signalling pathways
Program in Molecular Medicine
Medical Subject Headings
Animals; Humans; *MAP Kinase Signaling System; Tumor Necrosis Factor-alpha
Biochemistry | Cell Biology | Cellular and Molecular Physiology | Molecular Biology
The binding of tumour necrosis factor alpha (TNFalpha) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun NH2-terminal kinases (JNKs); and the p38 MAP kinases. These MAP kinase signalling pathways induce a secondary response by increasing the expression of several inflammatory cytokines (including TNFalpha) that contribute to the biological activity of TNFalpha. MAP kinases therefore function both upstream and down-stream of signalling by TNFalpha receptors. Here we review mechanisms that mediate these actions of MAP kinases during the response to TNFalpha.
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Citation: Semin Immunol. 2014 Jun;26(3):237-45. doi: 10.1016/j.smim.2014.02.009. Epub 2014 Mar 16. Link to article on publisher's site
ERK, JNK, MAP kinase, TNF, p38 MAP kinase
Sabio, Guadalupe and Davis, Roger J., "TNF and MAP kinase signalling pathways" (2014). Davis Lab Publications. 48.