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UMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
2014-06-01Keywords
AnimalsHumans
*MAP Kinase Signaling System
Tumor Necrosis Factor-alpha
ERK
JNK
MAP kinase
TNF
p38 MAP kinase
Biochemistry
Cell Biology
Cellular and Molecular Physiology
Molecular Biology
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Show full item recordAbstract
The binding of tumour necrosis factor alpha (TNFalpha) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun NH2-terminal kinases (JNKs); and the p38 MAP kinases. These MAP kinase signalling pathways induce a secondary response by increasing the expression of several inflammatory cytokines (including TNFalpha) that contribute to the biological activity of TNFalpha. MAP kinases therefore function both upstream and down-stream of signalling by TNFalpha receptors. Here we review mechanisms that mediate these actions of MAP kinases during the response to TNFalpha.Source
Semin Immunol. 2014 Jun;26(3):237-45. doi: 10.1016/j.smim.2014.02.009. Epub 2014 Mar 16. Link to article on publisher's siteDOI
10.1016/j.smim.2014.02.009Permanent Link to this Item
http://hdl.handle.net/20.500.14038/28320PubMed ID
24647229Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.smim.2014.02.009