Title

Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis

UMMS Affiliation

Program in Molecular Medicine

Date

9-22-2011

Document Type

Article

Medical Subject Headings

Animals; Antibodies, Monoclonal; *Autoimmunity; Cell Proliferation; Cell Separation; Cells, Cultured; Chronic Disease; Encephalomyelitis, Autoimmune,; Experimental; Eukaryotic Initiation Factor-4E; Female; Flow Cytometry; Humans; Interleukin-17; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiple Sclerosis; Phosphorylation; Polymerase Chain Reaction; Signal Transduction; Th17 Cells; p38 Mitogen-Activated Protein Kinases

Disciplines

Biochemistry | Cell Biology | Cellular and Molecular Physiology | Molecular Biology

Abstract

Although several transcription factors have been shown to be critical for the induction and maintenance of IL-17 expression by CD4 Th cells, less is known about the role of nontranscriptional mechanisms. Here we show that the p38 MAPK signaling pathway is essential for in vitro and in vivo IL-17 production by regulating IL-17 synthesis in CD4 T cells through the activation of the eukaryotic translation initiation factor 4E/MAPK-interacting kinase (eIF-4E/MNK) pathway. We also show that p38 MAPK activation is required for the development and progression of both chronic and relapsing-remitting forms of experimental allergic encephalomyelitis (EAE), the principal autoimmune model of multiple sclerosis. Furthermore, we show that regulation of p38 MAPK activity specifically in T cells is sufficient to modulate EAE severity. Thus, mechanisms other than the regulation of gene expression also contribute to Th17 cell effector functions and, potentially, to the pathogenesis of other Th17 cell-mediated diseases.

Rights and Permissions

Citation: Blood. 2011 Sep 22;118(12):3290-300. doi: 10.1182/blood-2011-02-336552. Epub 2011 Jul 25. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

21791428