Keep the 'phospho' on MAPK, be happy

UMMS Affiliation

Program in Molecular Medicine; Department of Psychiatry, Brudnick Neuropsychiatric Research Institute



Document Type

Response or Comment

Medical Subject Headings

Animals; Antidepressive Agents; Depression; Dual Specificity Phosphatase 1; Humans; Mice; Phosphorylation; Rats


Biochemistry | Cell Biology | Cellular and Molecular Physiology | Medicinal Chemistry and Pharmaceutics | Mental Disorders | Molecular Biology | Pharmacology


Depression ruins the lives of millions of people, causing dysphoria and anguish. New findings in rodents and human brain shed light on the mechanisms of this disease, uncovering a phosphatase as a new target to treat depressive behaviors. Comment on: A negative regulator of MAP kinase causes depressive behavior. [Nat Med. 2010]

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Citation: Nat Med. 2010 Nov;16(11):1187-8. doi: 10.1038/nm1110-1187. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID