This collection showcases the journal articles and other publications authored by researchers in the Roger Davis Lab in the Program in Molecular Medicine at the University of Massachusetts Medical School. The cJun NH2-terminal kinase (JNK) signal transduction pathway is implicated in several stress-related disease processes including cancer, diabetes, inflammation, and stroke. Our hope is that drugs targeting the JNK pathway may be useful for the treatment of these diseases. The goal of this laboratory is to understand the molecular processes that are engaged by JNK in both health and disease.

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Publications from 2016

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ASM Journals Eliminate Impact Factor Information from Journal Websites, Arturo Casadevall, Roger J. Davis, and ASM Journal Editors and Leadership

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Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury, Francisco Javier Cubero, Miguel Eugenio Zoubek, Wei Hu, Jin Peng, Gang Zhao, Yulia A. Nevzorova, Malika Al Masaoudi, Lars P. Bechmann, Mark V. Boekschoten, Michael Muller, Christian Preisinger, Nikolaus Gassler, Ali E. Canbay, Tom Luedde, Roger J. Davis, Christian Liedtke, and Christian Trautwein

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TNFalpha-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38alpha MAPK Pathway, Nomeda Girnius and Roger J. Davis

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Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma, Myoung Souk Han, Tamera Barrett, Michael A. Brehm, and Roger J. Davis

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Cell Signaling and Stress Responses, Gokhan S. Hotamisligil and Roger J. Davis

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), Daniel J. Klionsky, Roger J. Davis, Fen-Biao Gao, and Panagiotis D. Velentzas

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Tead and AP1 Coordinate Transcription and Motility, Xiangfan Liu, Huapeng Li, Mihir S. Rajurkar, Qi Li, Jennifer L. Cotton, Jianhong Ou, Lihua J. Zhu, Hira L. Goel, Arthur M. Mercurio, Joo-Seop Park, Roger J. Davis, and Junhao Mao

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alphavbeta6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor, Huimin Lu, Tao Wang, Zhong Jiang, Roger J. Davis, Thomas J. Fitzgerald, and Lucia R. Languino

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Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development, Kasmir Ramo, Koichi Sugamura, Siobhan M. Craige, John F. Keaney Jr., and Roger J. Davis

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beta1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation, Aejaz Sayeed, Huimin Lu, Qin Liu, David Deming Ii, Alexander Duffy, Peter McCue, Adam P. Dicker, Roger J. Davis, Dmitry Gabrilovich, Ulrich Rodeck, Dario C. Altieri, and Lucia R. Languino

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Inactivation of nuclear GSK3beta by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response, Tina M. Thornton, Pilar Delgado, Liang Chen, Beatriz Salas, Dimitry Krementsov, Miriam Fernandez, Santiago Vernia, Roger J. Davis, Ruth Heimann, Cory Teuscher, Michael S. Krangel, Almudena R. Ramiro, and Mercedes Rincon

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Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK, Santiago Vernia, Julie Cavanagh-Kyros, Tamera Barrett, Cathy Tournier, and Roger J. Davis

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An alternative splicing program promotes adipose tissue thermogenesis, Santiago Vernia, Yvonne J. K. Edwards, Myoung Souk Han, Julie Cavanagh-Kyros, Tamera Barrett, Jason K. Kim, and Roger J. Davis

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Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress, Santiago Vernia, Caroline Morel, Joseph C. Madara, Julie Cavanagh-Kyros, Tamera Barrett, Kathryn O. Chase, Norman J. Kennedy, Dae Young Jung, Jason K. Kim, Neil Aronin, Richard A. Flavell, Bradford B. Lowell, and Roger J. Davis

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Multisite phosphorylation by MAPK, Alan J. Whitmarsh and Roger J. Davis

Publications from 2015

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Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets, David M. Blodgett, Anetta Nowosielska, Shaked Afik, Susanne Pechhold, Anthony J. Cura, Norman J. Kennedy, Soyoung Kim, Alper Kucukural, Roger J. Davis, Sally C. Kent, Dale L. Greiner, Manuel Garber, David M. Harlan, and Philip J. diLorio Jr.

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Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury, Francisco Javier Cubero, Gang Zhao, Yulia A. Nevzorova, Maximilian Hatting, Malika Al Masaoudi, Julien Verdier, Jin Peng, Frederik M. Schaefer, Nadine Hermanns, Mark V. Boekschoten, Christoph Grouls, Nikolaus Gassler, Fabian Kiessling, Michael Muller, Roger J. Davis, Christian Liedtke, and Christian Trautwein

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p38alpha MAPK is required for tooth morphogenesis and enamel secretion, Matthew B. Greenblatt, Jung-Min Kim, Hwanhee Oh, Kwang Hwan Park, Min-Kyung Choo, Yasuyo Sano, Coralee E. Tye, Ziedonis Skobe, Roger J. Davis, Jin Mo Park, Marianna Bei, Laurie H. Glimcher, and Jae-Hyuck Shim

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Prostate Tumorigenesis Induced by PTEN Deletion Involves Estrogen Receptor beta Repression, Paul Mak, Jianrong Li, Sanjoy Samanta, Cheng Chang, D. Joseph Jerry, Roger J. Davis, Irwin Leav, and Arthur M. Mercurio

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JNK-interacting protein 1 mediates Alzheimer's-like pathological features in AICD-transgenic mice, Daniel R. Margevicius, Chinthasagar Bastian, Qingyuan Fan, Roger J. Davis, and Sanjay W. Pimplikar

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Presynaptic c-Jun N-terminal Kinase 2 regulates NMDA receptor-dependent glutamate release, Robert Nistico, Fulvio Florenzano, Dalila Mango, Caterina Ferraina, Massimo Grilli, Silvia Di Prisco, Annalisa Nobili, Stefania Saccucci, Marcello D'Amelio, Michela Morbin, Mario Marchi, Nicola B. Mercuri, Roger J. Davis, Anna Pittaluga, and Marco Feligioni

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Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes, Rachel J. Perry, Joao-Paulo G. Camporez, Romy Kursawe, Paul M. Titchenell, Dongyan Zhang, Curtis J. Perry, Michael J. Jurczak, Abulizi Abudukadier, Myoung Souk Han, Xian-Man Zhang, Hai-Bin Ruan, Xiaoyong Yang, Sonia Caprio, Susan M. Kaech, Hei Sook Sul, Morris J. Birnbaum, Roger J. Davis, Gary W. Cline, Kitt Falk Petersen, and Gerald I. Shulman

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Bone marrow-derived c-jun N-terminal kinase-1 (JNK1) mediates liver regeneration, Frederik M. Schaefer, Jin Peng, Wei Hu, Oliver Drvarov, Yulia A. Nevzorova, Gang Zhao, Malika Al. Masaoudi, Roger J. Davis, Christian Trautwein, and Francisco Javier Cubero

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Pathological axonal death through a MAPK cascade that triggers a local energy deficit, Jing Yang, Zhuhao Wu, Nicolas Renier, David J. Simon, Kunihiro Uryu, David S. Park, Peter A. Greer, Cathy Tournier, Roger J. Davis, and Marc Tessier-Lavigne

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Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5, Yongliang Zhang, Thang Nguyen, Peng Tang, Norman J. Kennedy, Huipeng Jiao, Mingliang Zhang, Joseph M. Reynolds, Anja Jaeschke, Natalia Martin-Orozco, Yeonseok Chung, Wei-min He, Chen Wang, Weiping Jia, Baoxue Ge, Roger J. Davis, Richard A. Flavell, and Chen Dong

Publications from 2014

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Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport, Kyoko Chiba, Masahiko Araseki, Keisuke Nozawa, Keiko Furukori, Yoichi Araki, Takahide Matsushima, Tadashi Nakaya, Saori Hata, Yuhki Saito, Seiichi Uchida, Yasushi Okada, Angus C. Nairn, Roger J. Davis, Tohru Yamamoto, Masataka Kinjo, Hidenori Taru, and Toshiharu Suzuki

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Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma, Clare C. Davies, Emma Harvey, Raymond F. T. McMahon, Katherine G. Finegan, Frances Connor, Roger J. Davis, David A. Tuveson, and Cathy Tournier

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Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts Ras-induced transformation, Avraham Maimon, Maxim Mogilevsky, Asaf Shilo, Regina Golan-Gerstl, Akram Obiedat, Vered Ben-Hur, Ilana Lebenthal-Loinger, Ilan Stein, Reuven Reich, Jonah Beenstock, Eldar Zehorai, Claus L. Andersen, Kasper Thorsen, Torben F. Orntoft, Roger J. Davis, Ben Davidson, David Mu, and Rotem Karni

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TNF and MAP kinase signalling pathways, Guadalupe Sabio and Roger J. Davis

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The PPARalpha-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway, Santiago Vernia, Julie Cavanagh, Luisa Garcia-Haro, Guadalupe Sabio, Tamera Barrett, Dae Young Jung, Jason K. Kim, Jia Xu, Hennady P. Shulha, Manuel Garber, Guangping Gao, and Roger J. Davis

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p38 MAPK regulates steroidogenesis through transcriptional repression of STAR gene, Syed Kashif Zaidi, Wen-Jun Shen, Stefanie Bittner, Alex Bittner, Mark P. McLean, Jiahuai Han, Roger J. Davis, Fredric B. Kraemer, and Salman Azhar

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Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis, Gang Zhao, Maximilian Hatting, Yulia A. Nevzorova, Jin Peng, Wei Hu, Mark V. Boekschoten, Tania Roskams, Michael Muller, Nikolaus Gassler, Christian Liedtke, Roger J. Davis, Francisco Javier Cubero, and Christian Trautwein

Publications from 2013

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beta1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase1, Hira Lal Goel, Aejaz Sayeed, Michael Breen, Matthew J. Zarif, David S. Garlick, Irwin Leav, Roger J. Davis, Thomas J. Fitzgerald, Andea Morrione, Chung-Cheng Hsieh, Qin Liu, Adam P. Dicker, Dario C. Altieri, and Lucia R. Languino

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Eukaryotic elongation factor 2 controls TNF-alpha translation in LPS-induced hepatitis, Barbara Gonzalez-Teran, Jose R. Cortes, Elisa Manieri, Nuria Matesanz, Angeles Verdugo, Maria E. Rodriguez, Agueda Gonzalez-Rodriguez, Angela M. Valverde, Pilar Martin, Roger J. Davis, and Guadalupe Sabio

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JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation, Myoung Souk Han, Dae Young Jung, Caroline Morel, Saquib A. Lakhani, Jason K. Kim, Richard A. Flavell, and Roger J. Davis

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Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways, Monica Imbernon, Daniel Beiroa, Maria J. Vazquez, Donald A. Morgan, Christelle Veyrat-Durebex, Begona Porteiro, Adenis Diaz-Arteaga, Ana Senra, Silvia Busquets, Douglas A. Velasquez, Omar Al-Massadi, Luis Varela, Marina Gandara, Francisco-Javier Lopez-Soriano, Rosalia Gallego, Luisa M. Seoane, Josep M. Argiles, Miguel Lopez, Roger J. Davis, Guadalupe Sabio, Francoise Rohner-Jeanrenaud, Kamal Rahmouni, Carlos Dieguez, and Ruben Nogueiras

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Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity, Shashi Kant, Tamera Barrett, Anastassiia Vertii, Yun Hee Noh, Dae Young Jung, Jason K. Kim, and Roger J. Davis

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Analysis of in vitro insulin-resistance models and their physiological relevance to in vivo diet-induced adipose insulin resistance, Kinyui Alice Lo, Adam Labadorf, Norman J. Kennedy, Myoung Souk Han, Yoon Sing Yap, Bryan Matthews, Xiaofeng Xin, Lei Sun, Roger J. Davis, Harvey F. Lodish, and Ernest Fraenkel

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Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipopolysaccharide and is required for phospholipid turnover in stimulated macrophages, Katya B. Rubinow, Valerie Z. Wall, Joel Nelson, Daniel Mar, Karol Bomsztyk, Bardia Askari, Marvin A. Lai, Kelly D. Smith, Myoung Souk Han, Anuradha Vivekanandan-Giri, Subramaniam Pennathur, Carolyn J. Albert, David A. Ford, Roger J. Davis, and Karin E. Bornfeldt

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Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway, Santiago Vernia, Julie Cavanagh-Kyros, Tamera Barrett, Dae Young Jung, Jason K. Kim, and Roger J. Davis

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JNK regulates compliance-induced adherens junctions formation in epithelial cells and tissues, Hui You, Roshan M. Padmashali, Aishwarya Ranganathan, Pedro Lei, Nomeda Girnius, Roger J. Davis, and Stelios T. Andreadis

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Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2, Jianxiu Yu, Rong Deng, Helen H. Zhu, Sharon S. Zhang, Changhong Zhu, Marc Montminy, Roger J. Davis, and Gen-Sheng Feng

Publications from 2012

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Role of JNK in mammary gland development and breast cancer, Cristina Arrigo Cellurale, Nomeda Girnius, Feng Jiang, Julie Cavanagh-Kyros, Shaolei Lu, David S. Garlick, Arthur M. Mercurio, and Roger J. Davis

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Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo, C. Clybouw, D. Merino, T. Nebl, F. Masson, M. Robati, L. O'Reilly, A. Hubner, Roger J. Davis, A. Strasser, and P. Bouillet

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Cell biology. A scaffold switch to insulate, Roger J. Davis

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VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer, Hira Lal Goel, Cheng Chang, Bryan M. Pursell, Irwin Leav, Stephen Lyle, Hualin Simon Xi, Chung-Cheng Hsieh, Helty Adisetiyo, Pradip Roy-Burman, Ilsa M. Coleman, Peter S. Nelson, Robert L. Vessella, Roger J. Davis, Stephen R. Plymate, and Arthur M. Mercurio

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JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate, Anette Hubner, David J. Mulholland, Claire L. Standen, Maria Karasarides, Julie Cavanagh-Kyros, Tamera Barrett, Hongbo Chi, Dale Greiner, Cathy Tournier, Charles L. Sawyers, Richard A. Flavell, Hong Wu, and Roger J. Davis

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The stress-activated protein kinases p38alpha/beta and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest, Alba Llopis, Noelia Salvador, Amaia Ercilla, Sandra Guaita-Esteruelas, Ivan del Barrantes Barco, Jalaj Gupta, Matthias Gaestel, Roger J. Davis, Angel R. Nebreda, and Neus Agell

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Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism, Julie Norseen, Tetsuya Hosooka, Ann Hammarstedt, Mark M. Yore, Shashi Kant, Pratik Aryal, Urban A. Kiernan, David A. Phillips, Hiroshi Maruyama, Bettina J. Kraus, Anny Usheva, Roger J. Davis, Ulf Smith, and Barbara B. Kahn

Publications from 2011

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Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation, Cristina Arrigo Cellurale, Guadalupe Sabio, Norman J. Kennedy, Madhumita Das, Marissa Bylsma, Peter Sandy, Tyler Jacks, and Roger J. Davis

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The role of JNK in the development of hepatocellular carcinoma, Madhumita Das, David S. Garlick, Dale Greiner, and Roger J. Davis

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Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity, Zhanguo Gao, Jin Zhang, Indu Kheterpal, Norman J. Kennedy, Roger J. Davis, and Jianping Ye

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TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway, Shashi Kant, Wojciech Swat, Sheng Zhang, Zhong-Yin Zhang, Benjamin G. Neel, Richard A. Flavell, and Roger J. Davis

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p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis, Jaemin Lee, Cheng Sun, Yingjiang Zhou, Justin Lee, Deniz Gokalp, Hilde Herrema, Sang Won. Park, Roger J. Davis, and Umut Ozcan

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Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload, Wei Liu, Min Zi, Hongbo Chi, Jiawei Jin, Sukhpal Prehar, Ludwig Neyses, Elizabeth J. Cartwright, Richard A. Flavell, Roger J. Davis, and Xin Wang

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The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo, Sonia Mazzitelli, Ping Xu, Isidre Ferrer, Roger J. Davis, and Cathy Tournier

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Translational control of NKT cell cytokine production by p38 MAPK, Viswas K. Nagaleekar, Guadalupe Sabio, Idil Aktan, Alan Chant, Isaac W. Howe, Tina M. Thornton, Patrick J. Benoit, Roger J. Davis, Mercedes Rincon, and Jonathan E. Boyson

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Fungal allergen beta-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells, Wendy A. Neveu, Edgar Bernardo, Jenna L. Allard, Viswas Nagaleekar, Matthew J. Wargo, Roger J. Davis, Yoichiro Iwakura, Laurie A. Whittaker, and Mercedes Rincon

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Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis, Rajkumar Noubade, Dimitry N. Krementsov, Roxana Del Rio, Tina Thornton, Viswas Nagaleekar, Naresha Saligrama, Anthony Spitzack, Karen Spach, Guadalupe Sabio, Roger J. Davis, Mercedes Rincon, and Cory Teuscher

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p38alpha Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis, Huei-Chi Wen, Alvaro Avivar-Valderas, Maria Soledad Sosa, Nomeda Girnius, Eduardo F. Farias, Roger J. Davis, and Julio A. Aguirre-Ghiso

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JNK regulates FoxO-dependent autophagy in neurons, Ping Xu, Madhumita Das, Judith Reilly, and Roger J. Davis

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MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice, Weiguo Zou, Matthew B. Greenblatt, Jae-Hyuck Shim, Shashi Kant, Bo Zhai, Sutada Lotinun, Nicholas Brady, Dorothy Zhang Hu, Steven P. Gygi, Roland Baron, Roger J. Davis, Dallas Jones, and Laurie H. Glimcher

Publications from 2010

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Platelet JNK1 is involved in secretion and thrombus formation, Frederic Adam, Alexandre Kauskot, Paquita Nurden, Eric Sulpice, Marc F. Hoylaerts, Roger J. Davis, Jean-Philippe Rosa, and Marijke Bryckaert

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Keep the 'phospho' on MAPK, be happy, Schahram Akbarian and Roger J. Davis

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Analysis of apoptosis of memory T cells and dendritic cells during the early stages of viral infection or exposure to toll-like receptor agonists, Kapil Bahl, Anette Hubner, Roger J. Davis, and Raymond M. Welsh

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Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration, Monia Barnat, Herve Enslen, Friedrich Propst, Roger J. Davis, Sylvia Soares, and Fatiha Nothias

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Role of JNK in a Trp53-dependent mouse model of breast cancer, Cristina Arrigo Cellurale, Claire R. Weston, Judith Reilly, David S. Garlick, D. Joseph Jerry, Hayla Karen Sluss, and Roger J. Davis

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The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice, Matthew B. Greenblatt, Jae-Hyuck Shim, Weiguo Zou, Despina Sitara, Michelle Schweitzer, Dorothy Hu, Sutada Lotinun, Yasuyo Sano, Roland Baron, Jin Mo Park, Simon Arthur, Min Xie, Michael D. Schneider, Bo Zhai, Steven Gygi, Roger J. Davis, and Laurie H. Glimcher

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JNK-mediated phosphorylation of Cdc25C regulates cell cycle entry and G(2)/M DNA damage checkpoint, Gustavo J. Gutierrez, Toshiya Tsuji, Janet V. Cross, Roger J. Davis, Dennis J. Templeton, Wei Jiang, and Ze'ev A. Ronai

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Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo, Anette Hubner, Julie Cavanagh-Kyros, Mercedes Rincon, Richard Flavell, and Roger J. Davis

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Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance, Caroline Morel, Claire L. Standen, Dae Young Jung, Susan Gray, Helena Ong, Richard A. Flavell, Jason K. Kim, and Roger J. Davis

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Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation, Monika Podkowa, Xin Zhao, Chi-Wing Chow, Eleanor T. Coffey, Roger J. Davis, and Liliana Attisano

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Differential activation of p38MAPK isoforms by MKK6 and MKK3, Gaelle Remy, Ana M. Risco, Francisco A. Inesta-Vaquera, Barbara Gonzalez-Teran, Guadalupe Sabio, Roger J. Davis, and Ana Cuenda

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Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1, Guadalupe Sabio, Julie Cavanagh-Kyros, Tamera Barrett, Dae Young Jung, Hwi Jin Ko, Helena Ong, Caroline Morel, Alfonso Mora, Judith Reilly, Jason K. Kim, and Roger J. Davis

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cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance, Guadalupe Sabio and Roger J. Davis

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Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance, Guadalupe Sabio, Norman J. Kennedy, Julie Cavanagh-Kyros, Dae Young Jung, Hwi Jin Ko, Helena Ong, Tamera Barrett, Jason K. Kim, and Roger J. Davis

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Hippocampal c-Jun-N-terminal kinases serve as negative regulators of associative learning, Tessi Sherrin, Thomas Blank, Cathrin Hippel, Martin Rayner, Roger J. Davis, and Cedomir Todorovic

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AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade, F. Donelson Smith, Lorene K. Langeberg, Cristina Arrigo Cellurale, Tony Pawson, Deborah K. Morrison, Roger J. Davis, and John D. Scott

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c-Jun NH2-terminal kinase is required for lineage-specific differentiation but not stem cell self-renewal, Ping Xu and Roger J. Davis

Publications from 2009

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Induction of hepatitis by JNK-mediated expression of TNF-alpha, Madhumita Das, Guadalupe Sabio, Feng Jiang, Mercedes Rincon, Richard Flavell, and Roger J. Davis

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Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage, Iva V. Klevernic, Simon Morton, Roger J. Davis, and Philip Cohen

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Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice, A. K. H. Lim, David J. Nikolic-Paterson, F. Y. Ma, E. Ozols, M. C. Thomas, Richard Flavell, Roger J. Davis, and Greg H. Tesch

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Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis, Caroline Morel, Scott M. Carlson, Forest M. White, and Roger J. Davis

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Regulation of the immune response by stress-activated protein kinases, Mercedes Rincon and Roger J. Davis

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Prevention of steatosis by hepatic JNK1, Guadalupe Sabio, Julie Cavanagh-Kyros, Hwi Jin Ko, Dae Young Jung, Susan Gray, John Y. Jun, Tamera Barrett, Alfonso Mora, Jason K. Kim, and Roger J. Davis

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Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes, Claire L. Standen, Norman J. Kennedy, Richard A. Flavell, and Roger J. Davis

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Nuclear localization of p38 MAPK in response to DNA damage, C. David Wood, Tina Thornton, Guadalupe Sabio, Roger J. Davis, and Mercedes Rincon

Publications from 2008

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Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1, John F. Alcorn, Amy S. Guala, Jos van der Velden, Brian McElhinney, Charles G. Irvin, Roger J. Davis, and Yvonne M.W. Janssen-Heininger

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Targeting dendritic cell signaling to regulate the response to immunization, David Escors, Luciene Lopes, Rongtuan Lin, John Hiscott, Shizuo Akira, Roger J. Davis, and Mary K. Collins

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Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention, Thomas J. Fitzgerald, Tao Wang, Hira Lal Goel, Jiayi Huang, Gary S. Stein, Jane B. Lian, Roger J. Davis, Stephen J. Doxsey, Kethandapatti C. Balaji, Jesse N. Aronowitz, and Lucia R. Languino

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MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model, Kyoichi Fukuda, Greg H. Tesch, Felicia Y. Yap, Josephine M. Forbes, Richard Flavell, Roger J. Davis, and David J. Nikolic-Paterson

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A genetically encoded fluorescent sensor of ERK activity, Christopher D. Harvey, Anka G. Ehrhardt, Cristina Arrigo Cellurale, Haining Zhong, Ryohei Yasuda, Roger J. Davis, and Karel Svoboda

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Multisite phosphorylation regulates Bim stability and apoptotic activity, Anette Hubner, Tamera Barrett, Richard Flavell, and Roger J. Davis

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c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway, Dong Hu, Wenfeng Fang, Anjia Han, Lindsay Gallagher, Roger J. Davis, Bin Xiong, and Wancai Yang

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Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice, Elizabeth Keramaris, Vladamir A. Ruzhynsky, Steve M. Callaghan, Estelle Wong, Roger J. Davis, Richard Flavell, Ruth S. Slack, and David S. Park

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Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex, Heidi Mendoza, David G. Campbell, Kerry Burness, James Hastie, Natalia Ronkina, Jae-Hyuck Shim, J. Simon C. Arthur, Roger J. Davis, Matthias Gaestel, Gary L. Johnson, Sankar Ghosh, and Philip Cohen

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Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage, Pat P. Ongusaha, Hank H. Qi, Lakshmi Raj, Young-Bum Kim, Stuart A. Aaronson, Roger J. Davis, Yang Shi, James K. Liao, and Sam W. Lee

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c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection, Joao H.F. Pedra, Jochen Mattner, Jian Tao, Steven M. Kerfoot, Roger J. Davis, Richard A. Flavell, Philip W. Askenase, Zhinan Yin, and Erol Fikrig

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A stress signaling pathway in adipose tissue regulates hepatic insulin resistance, Guadalupe Sabio, Madhumita Das, Alfonso Mora, Zhiyou Zhang, John Y. Jun, Hwi Jin Ko, Tamera Barrett, Jason K. Kim, and Roger J. Davis

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Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation, Tina Thornton, Gustavo Pedraza-Alva, Bin Deng, C. David Wood, Alexander Aronshtam, James L. Clements, Guadalupe Sabio, Roger J. Davis, Dwight E. Matthews, Bradley Doble, and Mercedes Rincon