UMMS Affiliation

Department of Pediatrics; Department of Quantitative Health Sciences

Date

5-5-2014

Document Type

Other

Disciplines

Endocrinology, Diabetes, and Metabolism | Pediatrics

Abstract

Background: The effects of vitamin D supplementation on mild hepatic dysfunction and glycemic control are unclear in children and adolescents with either type 1 (T1D) or type 2 diabetes (T2D).

Hypothesis: Vitamin D supplementation will improve hepatic dysfunction and glycemic control.

Aim: To determine the effect of vitamin D supplementation on alanine transaminase (ALT), hemoglobin A1c (HbA1c), and serum 25-hydroxyvitamin D [25(OH)D] concentration.

Subjects and Methods: A retrospective study of 131 subjects with either T1D (n=88: 46 females, 42 males), or T2D ( n=43: 26 females, 17 males) of ages 3-18 years between 2007-2013. All subjects had (1) a diagnosis of diabetes for >12 mo, (2) received vitamin D supplementation for the management of vitamin D deficiency (3) had baseline and subsequent simultaneous measurements of HbA1c, ALT, and 25(OH)D. Vitamin D deficiency was defined as 25(OH)D concentration of <50nmol/L (20 ng/mL).

Results: At baseline, vitamin D deficiency occurred in 72.1% of patients with T2D and in 37.5% of T1D patients (p

Conclusions: Vitamin D supplementation in subjects with T2D was associated with statistically significant decreases in BMI SDS, ALT, and a clinically-significant decrease in HbA1c.

Comments

This dataset (.xlsx file, 47 KB) is the primary data source for the following published study: Nwosu BU, Maranda L (2014) The Effects of Vitamin D Supplementation on Hepatic Dysfunction, Vitamin D Status, and Glycemic Control in Children and Adolescents with Vitamin D Deficiency and Either Type 1 or Type 2 Diabetes Mellitus. PLoS ONE 9(6): e99646. doi:10.1371/journal.pone.0099646.

Keywords

Type 1 diabetes, type 2 diabetes, vitamin D, hemoglobin A1c, alanine transaminase, liver dysfunction, children, adolescents

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