Enhancing Antibiotic Activity Using Nanomaterial-Antibiotic Conjugates
Authors
Jayawardena, H. Surangi N.De Zoysa, Thareendra
Jayawardana, Kalana W.
Boiko, Scott T.
Yan, Mingdi
Document Type
Poster AbstractPublication Date
2014-05-20Keywords
Bacterial Infections and MycosesChemical and Pharmacologic Phenomena
Medicinal-Pharmaceutical Chemistry
Nanomedicine
Translational Medical Research
Metadata
Show full item recordAbstract
We demonstrate that streptomycin conjugated on silica nanoparticles (SNP-Str) can be used to effectively target streptomycin-resistant Escherichia coli (E. coli) bacteria by lowering the minimum inhibitory concentration (MIC) of streptomycin up to 2 log folds. Silica nanoparticles were synthesized with an average diameter of 80, 50 and 30 nm, respectively. Streptomycin was then covalently conjugated to SNP using efficient photocoupling chemistry. The MIC for free streptomycin sulfate was recorded as a high 2.0 mg/mL for an engineered Strr mutant E. coli ORN 208. Conjugating the streptomycin to SNP resulted in the decrease in MIC to 161 μg/mL, 63 μg/mL, and 19 μg/mL for SNP of 80, 50 and 30 nm, respectively. In this poster, the synthesis, characterization, and evaluation of SNP-Str will be presented and discussed.DOI
10.13028/ec20-m967Permanent Link to this Item
http://hdl.handle.net/20.500.14038/27964Notes
Abstract of poster presented at the 2014 UMass Center for Clinical and Translational Science Research Retreat, held on May 20, 2014 at the University of Massachusetts Medical School, Worcester, Mass.
Rights
Copyright the Author(s)Distribution License
http://creativecommons.org/licenses/by-nc-sa/3.0/ae974a485f413a2113503eed53cd6c53
10.13028/ec20-m967